...
...
Read Article
- More Betting
Missouri vs. Oklahoma prediction: Oklahoma favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Missouri vs Oklahoma predictions for college football Saturday.
Oklahoma and Missouri will clash in Week 13 college football action at Gaylord Family Oklahoma Memorial Stadium on Saturday, beginning at 12:00PM ET.
Based on updated simulations, Dimers' proven college football model predicts Oklahoma as the most likely winner of the Missouri vs. Oklahoma game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Missouri vs. Oklahoma prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Missouri vs. Oklahoma 10,000 times as part of our college football predictions coverage.
Our independent predictive model gives Oklahoma a 68% chance of beating Missouri. Our predicted final score has Oklahoma winning 25-19.
According to our model, Oklahoma (-4.5) has a 52% chance of covering the spread, while the 42.5-point over/under has a 56% chance of staying under.
Missouri vs. Oklahoma odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Missouri | Oklahoma |
|---|---|---|
| Spread | +4.5 (-108) | -4.5 (-105) |
| Moneyline | +180 | -196 |
| Total | o42.5 (-115) | u42.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Missouri vs. Oklahoma picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Oklahoma -4.5 | -105 |
| Moneyline | Oklahoma | -196 |
| Total | Under 42.5 | -105 |
According to our best college football bets, the top play to make on this game is Under 42.5 total points.
Missouri vs. Oklahoma game-day updates and essential details
Saturday's college football action between Oklahoma and Missouri at Gaylord Family Oklahoma Memorial Stadium is scheduled to begin at 12:00PM ET.
- Who: Missouri vs. Oklahoma
- Date: Saturday, November 22, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Gaylord Family Oklahoma Memorial Stadium
Sports betting deal available for Missouri sports fans
To make the most of the upcoming Missouri launch, check out details on the latest Bet365 bonus code "DIMERS" that secures $365 in bonus bets from a $10 bet — win or lose. Don't miss out!
Conclusion
We predict Oklahoma, with a 68% win probability, will likely beat Missouri on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Missouri vs. Oklahoma insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure