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Mississippi State vs. Missouri prediction: Why Missouri is favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Mississippi State vs Missouri predictions for college football Saturday.
Missouri will face Mississippi State in Week 12 college football action at Memorial Stadium/Faurot Field on Saturday, with kickoff at 7:45PM ET.
Based on the latest simulation results, Dimers' proven college football model predicts Missouri as the most likely winner of the Mississippi State vs. Missouri game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Mississippi State vs. Missouri prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Mississippi State vs. Missouri 10,000 times as part of our college football predictions coverage.
Our independent predictive model currently gives Missouri a 64% chance of beating Mississippi State. Our predicted final score has Missouri winning 29-23.
According to our model, Mississippi State (+7.5) has a 58% chance of covering the spread, while the 50.5-point over/under has a 56% chance of staying under.
Mississippi State vs. Missouri odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Mississippi State | Missouri |
|---|---|---|
| Spread | +7.5 (-112) | -7.5 (+100) |
| Moneyline | +225 | -260 |
| Total | o50.5 (-110) | u50.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Mississippi State vs. Missouri picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Mississippi State +7.5 | -112 |
| Moneyline | Mississippi State | +225 |
| Total | Under 50.5 | -108 |
According to our college football best bets, the top play to make on this game is Mississippi State to win.
Mississippi State vs. Missouri game-day updates and essential details
Saturday's college football action between Missouri and Mississippi State at Memorial Stadium/Faurot Field is scheduled to start at 7:45PM ET.
- Who: Mississippi State vs. Missouri
- Date: Saturday, November 15, 2025
- Time: 7:45PM ET/4:45PM PT
- Venue: Memorial Stadium/Faurot Field
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To make the most of Saturday's mammoth day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that unlocks $200 in bonus bets from a $5 bet — win or lose. Don't miss out!
Conclusion
We predict Missouri, with a 64% win probability, will likely beat Mississippi State on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Mississippi State vs. Missouri insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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