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Twins vs. Orioles prediction: Baltimore favored to win MLB Opening Day matchup [3/26/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Minnesota Twins vs Baltimore Orioles predictions for MLB Thursday.
MLB opening day action continues on Thursday at 3:05 PM ET as the Minnesota Twins take on the Baltimore Orioles at Oriole Park at Camden Yards.
The Orioles will send Trevor Rogers (0-0, 0.00 ERA) to the mound, pitting him against Joe Ryan (0-0, 0.00 ERA) for the Twins.
Based on the latest simulations, Dimers' refined MLB model predicts the Orioles as the most likely winner of the Twins vs. Orioles game.
This article offers an expanded analysis of Thursday's matchup, including best bets and picks.
Twins vs. Orioles prediction: Who will win on MLB Opening Day?
Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's MLB matchup between the Twins and Orioles, forming part of our MLB predictions coverage.
Our leading predictive model gives the Orioles a 56% chance of beating the Twins.
According to our model, the Twins (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 57% chance of going over.
Twins vs. Orioles odds [3/26/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Twins | Orioles |
|---|---|---|
| Run Line | +1.5 (-176) | -1.5 (+158) |
| Moneyline | +120 | -135 |
| Total | o8.5 (-105) | u8.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Twins vs. Orioles picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Orioles -1.5 | +158 |
| Moneyline | Twins | +120 |
| Total | Over 8.5 | -105 |
According to our MLB best bets, the top play to make on this game is Over 8.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Twins vs. Orioles game-day updates and essential details
Thursday's MLB game between the Orioles and Twins at Oriole Park at Camden Yards is scheduled to commence at 3:05 PM ET.
- Who: Minnesota Twins vs. Baltimore Orioles
- Date: Thursday, March 26, 2026
- Time: 3:05 PM ET/12:05PM PT
- Venue: Oriole Park at Camden Yards
Conclusion
We predict the Orioles, with a 56% win probability, will likely beat the Twins on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Twins vs. Orioles insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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