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Michigan vs. Northwestern prediction: Michigan favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Michigan vs Northwestern predictions for college football Saturday.
Northwestern will take on the favored Michigan in Week 12 college football action at Wrigley Field on Saturday, beginning at 12:00PM ET.
Based on updated simulation results, Dimers' advanced college football model predicts Michigan as the most likely winner of the Michigan vs. Northwestern game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Michigan vs. Northwestern prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Michigan vs. Northwestern 10,000 times as part of our college football predictions coverage.
Our famous predictive model currently gives Michigan a 78% chance of beating Northwestern. Our predicted final score has Michigan winning 26-17.
According to our model, Northwestern (+10.5) has a 54% chance of covering the spread, while the over/under total of 42.5 points has a 59% chance of staying under.
Michigan vs. Northwestern odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Michigan | Northwestern |
|---|---|---|
| Spread | -10.5 (-104) | +10.5 (-110) |
| Moneyline | -425 | +340 |
| Total | o42.5 (-110) | u42.5 (-120) |
All odds are correct at the time of publication and are subject to change.
Michigan vs. Northwestern picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Northwestern +10.5 | -110 |
| Moneyline | Northwestern | +340 |
| Total | Under 42.5 | -120 |
According to our best college football bets, the top play to make on this game is Under 42.5 total points.
Michigan vs. Northwestern game-day updates and essential details
Saturday's college football matchup between Northwestern and Michigan at Wrigley Field is scheduled to start at 12:00PM ET.
- Who: Michigan vs. Northwestern
- Date: Saturday, November 15, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Wrigley Field
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Conclusion
We predict Michigan, with a 78% win probability, will likely beat Northwestern on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Michigan vs. Northwestern insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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