Michigan State vs. Indiana prediction: Why Indiana is favored to win in college football Week 8, 2025

Indiana and Michigan State will meet in Week 8 college football action at Memorial Stadium on Saturday, starting at 3:30PM ET.

Based on updated simulation results, Dimers' advanced college football model projects the Indiana as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Michigan State vs. Indiana predictions page.

Michigan State vs. Indiana prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Michigan State vs. Indiana 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Indiana a 95% chance of defeating Michigan State. Our predicted final score has Indiana winning 38-13.

According to our model, Michigan State (+26.5) has a 52% chance of covering the spread, while the 49.5-point over/under has a 55% chance of staying under.

Michigan State vs. Indiana odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Michigan State	Indiana
Spread	+26.5 (-110)	-26.5 (-106)
Moneyline	+1750	-3600
Total	o49.5 (-105)	u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Michigan State vs. Indiana picks and best bets

Our model's biggest edge in today's Michigan State vs. Indiana matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Michigan State vs. Indiana game-day updates and essential details

Saturday's college football game between Indiana and Michigan State at Memorial Stadium is scheduled to start at 3:30PM ET.

• Who: Michigan State vs. Indiana
• Date: Saturday, October 18, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: Memorial Stadium

Dimers' in-depth preview of Saturday's Michigan State vs. Indiana matchup includes our prediction, picks and the latest betting odds.

Before making any Michigan State vs. Indiana picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Indiana, with a 95% win probability, will likely beat Michigan State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Michigan State vs. Indiana insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on college football

Stay up-to-date with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the most accurate probabilities for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.