Miami Ohio vs. Buffalo prediction: Buffalo favored to win in college football Week 13, 2025

Buffalo and Miami Ohio will meet in Week 13 college football action at UB Stadium on Wednesday, beginning at 7:00PM ET.

Based on the latest simulations, Dimers' advanced college football model gives Buffalo a slight edge with a 51% win probability over Miami Ohio.

This article offers a closer look at Wednesday's Miami Ohio vs. Buffalo matchup, including an expanded look at the predicted score, best bets and picks.

Miami Ohio vs. Buffalo prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Miami Ohio vs. Buffalo 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Buffalo a 51% chance of beating Miami Ohio. Our predicted score is Miami Ohio 20-20 Buffalo.

According to our model, Buffalo (+2.5) has a 54% chance of covering the spread, while the over/under total of 38.5 points has a 54% chance of staying under.

While there is no way for a College Football game to end in a tie, our prediction of 20-20 is based on each team's average score in the above-mentioned simulations of Miami Ohio vs. Buffalo.

Miami Ohio vs. Buffalo odds

We have sourced the best College Football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Miami Ohio vs. Buffalo picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best college football bets, the top play to make on this game is Buffalo to win.

Miami Ohio vs. Buffalo game-day updates and essential details

Wednesday's college football matchup between Buffalo and Miami Ohio at UB Stadium is scheduled to begin at 7:00PM ET.

• Who: Miami Ohio vs. Buffalo
• Date: Wednesday, November 19, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: UB Stadium

Conclusion

We predict Buffalo, with a 51% win probability, will likely beat Miami Ohio on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Miami Ohio vs. Buffalo insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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