LSU vs. Vanderbilt prediction: Vanderbilt favored to win in college football Week 8, 2025

Vanderbilt will face LSU in Week 8 college football action at FirstBank Stadium on Saturday, starting at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts the Vanderbilt as the most likely winner of today's game.

For expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive LSU vs. Vanderbilt predictions page.

LSU vs. Vanderbilt prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of LSU vs. Vanderbilt 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Vanderbilt a 57% chance of beating LSU. Our predicted final score has Vanderbilt winning 25-23.

According to our model, Vanderbilt (-1.5) has a 52% chance of covering the spread, while the over/under total of 48.5 points has a 52% chance of staying under.

LSU vs. Vanderbilt odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	LSU	Vanderbilt
Spread	+1.5 (-110)	-1.5 (-108)
Moneyline	+102	-118
Total	o48.5 (-105)	u48.5 (-115)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

LSU vs. Vanderbilt picks and best bets

Our model's biggest edge in today's LSU vs. Vanderbilt matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

LSU vs. Vanderbilt game-day updates and essential details

Saturday's college football action between Vanderbilt and LSU at FirstBank Stadium is scheduled to begin at 12:00PM ET.

• Who: LSU vs. Vanderbilt
• Date: Saturday, October 18, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: FirstBank Stadium

Dimers' full preview of Saturday's LSU vs. Vanderbilt matchup includes our prediction, picks and the latest betting odds.

Before making any LSU vs. Vanderbilt picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's enormous day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose.

Plus, find out all the details on the BetMGM x Dimers Pro offer which provides a great option for those looking to expand their sports betting horizons. Don't miss out!

Conclusion

We predict Vanderbilt, with a 57% win probability, will likely beat LSU on Saturday.

AI and automation have enhanced this article to quickly deliver accurate LSU vs. Vanderbilt insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Keep up with the latest college football betting news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the most up-to-date projections for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.