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Louisville vs. SMU prediction: Southern Methodist favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Louisville vs SMU predictions for college football Saturday.
Southern Methodist will face Louisville in Week 13 college football action at Gerald J. Ford Stadium on Saturday, starting at 12:00PM ET.
Based on the latest simulations, Dimers' advanced college football model predicts Southern Methodist as the most likely winner of the Louisville vs. SMU game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Louisville vs. SMU prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Louisville vs. SMU 10,000 times as part of our college football predictions coverage.
Our famous predictive model gives Southern Methodist a 55% chance of defeating Louisville. Our predicted final score has Southern Methodist winning 25-24.
According to our model, Louisville (+4) has a 61% chance of covering the spread, while the 48.5-point over/under has a 52% chance of going over.
Louisville vs. SMU odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Louisville | SMU |
|---|---|---|
| Spread | +4 (-112) | -4 (-108) |
| Moneyline | +155 | -178 |
| Total | o48.5 (-115) | u48.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. SMU picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville +4 | -112 |
| Moneyline | Louisville | +155 |
| Total | Over 48.5 | -115 |
According to our college football best bets, the top play to make on this game is Louisville +4 at the spread.
Louisville vs. SMU game-day updates and essential details
Saturday's college football game between SMU and Louisville at Gerald J. Ford Stadium is scheduled to commence at 12:00PM ET.
- Who: Louisville vs. Southern Methodist
- Date: Saturday, November 22, 2025
- Time: 12:00PM ET/9:00AM PT
- Venue: Gerald J. Ford Stadium
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Conclusion
We predict Southern Methodist, with a 55% win probability, will likely beat Louisville on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Southern Methodist insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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