Lakers vs. Clippers prediction: Clippers to win, Luka Doncic projected for big game in Thursday's NBA matchup [1/22/2026]

The Los Angeles Clippers will square off with the Los Angeles Lakers in NBA action at Intuit Dome on Thursday, starting at 10:00 PM ET.

Based on the latest simulation results and today’s injury news, Dimers' proven NBA model projects the Clippers as the most likely winner of the Lakers vs. Clippers game.

This prediction follows the latest NBA Injury Report, which suggests the Clippers lineup will feature players like Kawhi Leonard, James Harden and John Collins, while the Lakers will be led by Luka Doncic, LeBron James and Deandre Ayton.

Doncic is expected to shine with a projected 32 points and 4 threes.

This article offers a closer look at Thursday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Lakers vs. Clippers prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the result of Thursday's NBA game between the Lakers and Clippers 10,000 times as part of our NBA predictions coverage.

Our independent predictive model currently gives the Clippers a 59% chance of defeating the Lakers. Our predicted final score has the Clippers winning 112-110.

According to our model, the bookmakers have got it right, and the Lakers and Clippers each have a 50% chance of covering the spread, while the over/under total of 224.5 points has a 51% chance of staying under.

Lakers vs. Clippers odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Lakers vs. Clippers picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Thursday, the top play to make on this game is Clippers to win.

Lakers vs. Clippers player props

NBA player props are an exciting way to wager on Thursday's Lakers vs. Clippers matchup without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Intuit Dome.

Luka Doncic is expected to lead the Lakers with 32 points, 7 rebounds and 8 assists, while Kawhi Leonard is projected to have 29 points, 6 rebounds and 3 assists for the Clippers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.

Lakers prediction

Our model's projected player stats for the Lakers are:

Clippers prediction

Projected points, rebounds, assists and three-pointers made for the Clippers:

Lakers vs. Clippers game-day updates and essential details

Thursday's action between the Clippers and Lakers at Intuit Dome is scheduled to begin at 10:00 PM ET.

• Who: Los Angeles Lakers vs. Los Angeles Clippers
• Date: Thursday, January 22, 2026
• Time: 10:00 PM ET/7:00PM PT
• Venue: Intuit Dome

Conclusion

We predict the Clippers, with a 59% win probability, will likely beat the Lakers on Thursday, with Luka Doncic projected for a game-high 61 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Lakers vs. Clippers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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