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Read Article Dodgers vs. Giants prediction: Dodgers favored to win Wednesday's MLB matchup [4/22/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Los Angeles Dodgers vs San Francisco Giants predictions for MLB Wednesday.
The San Francisco Giants and Los Angeles Dodgers are scheduled to meet in MLB action at Oracle Park on Wednesday, starting at 9:45 PM ET.
The Giants will have Tyler Mahle (0-3, 7.23 ERA) as their starting pitcher, up against Shohei Ohtani (2-0, 0.50 ERA) for the Dodgers.
Based on the latest simulation results, Dimers' proven MLB model projects the Dodgers as the most likely winner of the Dodgers vs. Giants game.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
Dodgers vs. Giants prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Dodgers and Giants, forming part of our MLB predictions coverage.
Our leading predictive model gives the Dodgers a 63% chance of beating the Giants.
According to our model, the bookmakers have got it right, and the Dodgers and Giants each have a 50% chance of covering the run line, while the over/under total of 7.5 runs has a 54% chance of going over.
Dodgers vs. Giants odds [4/22/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Dodgers | Giants |
|---|---|---|
| Run Line | -1.5 (-118) | +1.5 (+105) |
| Moneyline | -205 | +172 |
| Total | o7.5 (-115) | u7.5 (-102) |
All odds are correct at the time of publication and are subject to change.
Dodgers vs. Giants picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Giants +1.5 | +105 |
| Moneyline | Giants | +172 |
| Total | Over 7.5 | -115 |
According to our MLB best bets, the top play to make on this game is Giants +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Dodgers vs. Giants game-day updates and essential details
Wednesday's MLB action between the Giants and Dodgers at Oracle Park is scheduled to commence at 9:45 PM ET.
- Who: Los Angeles Dodgers vs. San Francisco Giants
- Date: Wednesday, April 22, 2026
- Time: 9:45 PM ET/6:45PM PT
- Venue: Oracle Park
Conclusion
We predict the Dodgers, with a 63% win probability, will likely beat the Giants in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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