Lafayette vs. Holy Cross prediction: Lafayette favored to win in college football Week 10, 2025

Holy Cross will square off with Lafayette in Week 10 college football action at Fitton Field on Saturday, with kickoff at 1:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts the Lafayette as the most likely winner of the Lafayette vs. Holy Cross game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Lafayette vs. Holy Cross prediction: Who will win, cover the spread?

Using powerful machine learning and data analysis, we have simulated the result of Lafayette vs. Holy Cross 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Lafayette a 58% chance of beating Holy Cross. Our predicted final score has Lafayette winning 27-24.

According to our model, Holy Cross (+3.5) has a 56% chance of covering the spread, while the 50.5-point over/under has a 53% chance of staying under.

Lafayette vs. Holy Cross odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Lafayette	Holy Cross
Spread	-3.5 (+100)	+3.5 (-120)
Moneyline	-148	+130
Total	o50.5 (-110)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

Lafayette vs. Holy Cross picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Holy Cross +3.5	-120
Moneyline	Holy Cross	+130
Total	Under 50.5	-110

According to our college football best bets, the top play to make on this game is Holy Cross +3.5 at the spread.

Lafayette vs. Holy Cross game-day updates and essential details

Saturday's college football action between Holy Cross and Lafayette at Fitton Field is scheduled to begin at 1:00PM ET.

• Who: Lafayette vs. Holy Cross
• Date: Saturday, November 1, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Fitton Field

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Conclusion

We predict Lafayette, with a 58% win probability, will likely beat Holy Cross on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Lafayette vs. Holy Cross insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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