James Madison vs. Oregon prediction: Oregon favored to win in college football playoffs first round [2025]

Oregon will face James Madison in Week 17 college football playoffs action at Autzen Stadium on Saturday, starting at 7:30 PM ET.

Based on updated simulations, Dimers' advanced college football model projects Oregon as the most likely winner of the James Madison vs. Oregon game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

James Madison vs. Oregon prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of James Madison vs. Oregon 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Oregon a 93% chance of defeating James Madison and advancing to play Texas Tech in the Orange Bowl Bowl. Our predicted final score has Oregon winning 33-13.

According to our model, the bookies have got it right, and James Madison and Oregon each have a 50% chance of covering the spread, while the over/under total of 46.5 points has a 54% chance of staying under.

James Madison vs. Oregon odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

James Madison vs. Oregon picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: