...
...
Read Article
Iowa vs. Vanderbilt prediction: Vanderbilt favored to win ReliaQuest Bowl [2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Iowa vs Vanderbilt predictions for college football Wednesday.
Vanderbilt will square off with Iowa in the 2025 ReliaQuest Bowl at Raymond James Stadium on Wednesday, starting at 12:00 PM ET.
Based on updated simulations, Dimers' advanced college football model predicts Vanderbilt as the most likely winner of the Iowa vs. Vanderbilt game.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
ReliaQuest Bowl prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of the 2025 ReliaQuest Bowl 10,000 times as part of our college football predictions coverage.
Our leading predictive model currently gives Vanderbilt a 63% chance of defeating Iowa. Our predicted final score has Vanderbilt winning 25-21.
According to our model, Vanderbilt (-3.5) has a 53% chance of covering the spread, while the over/under total of 47.5 points has a 52% chance of staying under.
ReliaQuest Bowl odds
We have researched the best college football odds in America for this game, which are listed here:
| Bet Type | Iowa | Vanderbilt |
|---|---|---|
| Spread | +3.5 (-115) | -3.5 (-102) |
| Moneyline | +140 | -156 |
| Total | o47.5 (-104) | u47.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Iowa vs. Vanderbilt picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Vanderbilt -3.5 | -102 |
| Moneyline | Vanderbilt | -156 |
| Total | Under 47.5 | -115 |
According to our college football best bets, the top play to make on this game is Vanderbilt -3.5 at the spread.
Iowa vs. Vanderbilt game-day updates and essential details
Wednesday's college football matchup between Vanderbilt and Iowa at Raymond James Stadium is scheduled to commence at 12:00 PM ET.
- Who: Iowa vs. Vanderbilt
- Date: Wednesday, December 31, 2025
- Time: 12:00 PM ET/9:00AM PT
- Venue: Raymond James Stadium
Conclusion
We predict Vanderbilt, with a 63% win probability, will likely beat Iowa on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Iowa vs. Vanderbilt insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure