Iowa vs. Vanderbilt prediction: Vanderbilt favored to win ReliaQuest Bowl [2025]

Vanderbilt will take on Iowa in the 2025 ReliaQuest Bowl at Raymond James Stadium on Wednesday, starting at 12:00 PM ET.

Based on the latest simulation results, Dimers' advanced college football model predicts Vanderbilt as the most likely winner of the Iowa vs. Vanderbilt game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

ReliaQuest Bowl prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of the 2025 ReliaQuest Bowl 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Vanderbilt a 66% chance of beating Iowa. Our predicted final score has Vanderbilt winning 25-20.

According to our model, the bookmakers have got it right, and Iowa and Vanderbilt each have a 50% chance of covering the spread, while the over/under total of 45.5 points also has an equal 50-50 chance of hitting.

ReliaQuest Bowl odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Iowa vs. Vanderbilt picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: