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Iowa vs. Southern California prediction: Southern California favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Iowa vs Southern California predictions for college football Saturday.
Southern California will take on Iowa in Week 12 college football action at Los Angeles Memorial Coliseum on Saturday, with kickoff at 3:30PM ET.
Based on updated simulations, Dimers' advanced college football model predicts Southern California as the most likely winner of the Iowa vs. Southern California game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Iowa vs. Southern California prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the outcome of Iowa vs. Southern California 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Southern California a 63% chance of defeating Iowa. Our predicted final score has Southern California winning 26-21.
According to our model, Iowa (+6.5) has a 55% chance of covering the spread, while the over/under total of 48.5 points has an equal 50-50 chance of hitting.
Iowa vs. Southern California odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Iowa | Southern California |
|---|---|---|
| Spread | +6.5 (-105) | -6.5 (-112) |
| Moneyline | +200 | -230 |
| Total | o48.5 (-105) | u48.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Iowa vs. Southern California picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Iowa +6.5 | -105 |
| Moneyline | Iowa | +200 |
| Total | Over 48.5 | -105 |
According to our best college football bets, the top play to make on this game is Iowa +6.5 at the spread.
Iowa vs. Southern California game-day updates and essential details
Saturday's college football game between Southern California and Iowa at Los Angeles Memorial Coliseum is scheduled to start at 3:30PM ET.
- Who: Iowa vs. Southern California
- Date: Saturday, November 15, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Los Angeles Memorial Coliseum
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Conclusion
We predict Southern California, with a 63% win probability, will likely beat Iowa on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Iowa vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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