Indiana vs. Maryland prediction: Why Indiana is favored to win in college football Week 10, 2025

Maryland and Indiana will clash in Week 10 college football action at SECU Stadium on Saturday, with kickoff at 3:30PM ET.

Based on updated simulation results, Dimers' proven college football model projects the Indiana as the most likely winner of the Indiana vs. Maryland game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Indiana vs. Maryland prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Indiana vs. Maryland 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Indiana a 92% chance of defeating Maryland. Our predicted final score has Indiana winning 35-14.

According to our model, the bookmakers have got it right, and Indiana and Maryland each have a 50% chance of covering the spread, while the over/under total of 50.5 points also has an equal 50-50 chance of hitting.

Indiana vs. Maryland odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Indiana	Maryland
Spread	-21.5 (-105)	+21.5 (-115)
Moneyline	-2000	+1100
Total	o50.5 (-115)	u50.5 (-105)

All odds are correct at the time of publication and are subject to change.

Indiana vs. Maryland picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Indiana -21.5	-105
Moneyline	Maryland	+1100
Total	Under 50.5	-105

According to our college football best bets, the top play to make on this game is Maryland to win.

Indiana vs. Maryland game-day updates and essential details

Saturday's college football game between Maryland and Indiana at SECU Stadium is scheduled to commence at 3:30PM ET.

• Who: Indiana vs. Maryland
• Date: Saturday, November 1, 2025
• Time: 3:30PM ET/12:30PM PT
• Venue: SECU Stadium

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Conclusion

We predict Indiana, with a 92% win probability, will likely beat Maryland on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Indiana vs. Maryland insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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