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Illinois State vs. South Dakota State prediction: South Dakota State favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Illinois State vs South Dakota State predictions for college football Saturday.
South Dakota State and Illinois State will lock horns in Week 12 college football action at Dana J. Dykhouse Stadium on Saturday, commencing at 3:00PM ET.
Based on updated simulation results, Dimers' advanced college football model predicts South Dakota State as the most likely winner of the Illinois State vs. South Dakota State game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Illinois State vs. South Dakota State prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Illinois State vs. South Dakota State 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives South Dakota State a 65% chance of defeating Illinois State. Our predicted final score has South Dakota State winning 27-22.
According to our model, South Dakota State (-3) has a 56% chance of covering the spread, while the 52.5-point over/under has a 53% chance of staying under.
Illinois State vs. South Dakota State odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Illinois State | South Dakota State |
|---|---|---|
| Spread | +3 (-110) | -3 (-110) |
| Moneyline | +145 | -156 |
| Total | o52.5 (-105) | u52.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Illinois State vs. South Dakota State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Dakota State -3 | -110 |
| Moneyline | South Dakota State | -156 |
| Total | Under 52.5 | -115 |
According to our college football best bets, the top play to make on this game is South Dakota State to win.
Illinois State vs. South Dakota State game-day updates and essential details
Saturday's college football action between South Dakota State and Illinois State at Dana J. Dykhouse Stadium is scheduled to commence at 3:00PM ET.
- Who: Illinois State vs. South Dakota State
- Date: Saturday, November 15, 2025
- Time: 3:00PM ET/12:00PM PT
- Venue: Dana J. Dykhouse Stadium
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Conclusion
We predict South Dakota State, with a 65% win probability, will likely beat Illinois State on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Illinois State vs. South Dakota State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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