Illinois State vs. South Dakota prediction: South Dakota favored to win in college football Week 9, 2025

South Dakota will take on Illinois State in Week 9 college football action at The DakotaDome on Saturday, starting at 2:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the South Dakota as the most likely winner of the Illinois State vs. South Dakota game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Illinois State vs. South Dakota prediction: Who will win, cover the spread?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Illinois State vs. South Dakota 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives South Dakota a 60% chance of defeating Illinois State. Our predicted final score has South Dakota winning 29-25.

According to our model, the bookmakers have got it right, and Illinois State and South Dakota each have a 50% chance of covering the spread, while the 54.5-point over/under also has an equal 50-50 chance of hitting.

Illinois State vs. South Dakota odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Illinois State	South Dakota
Spread	+3.5 (-110)	-3.5 (-110)
Moneyline	+164	-172
Total	o54.5 (-110)	u54.5 (-110)

All odds are correct at the time of publication and are subject to change.

Illinois State vs. South Dakota picks and best bet

Our probabilities, matched with the available odds, reveal the top betting picks to place on this game, detailed in Dimers' best college football bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Illinois State +3.5	-110
Moneyline	Illinois State	+164
Total	Under 54.5	-110

According to our college football best bets, the top play to make on this game is Illinois State moneyline.

Illinois State vs. South Dakota game-day updates and essential details

Saturday's college football action between South Dakota and Illinois State at The DakotaDome is scheduled to begin at 2:00PM ET.

• Who: Illinois State vs. South Dakota
• Date: Saturday, October 25, 2025
• Time: 2:00PM ET/11:00AM PT
• Venue: The DakotaDome

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Conclusion

We predict South Dakota, with a 60% win probability, will likely beat Illinois State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Illinois State vs. South Dakota insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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