Astros vs. Rockies prediction: Why Houston is favored to win Monday's MLB matchup [4/6/2026]

The Colorado Rockies will face the Houston Astros in MLB action at Coors Field on Monday, commencing at 8:40 PM ET.

The Rockies will start Ryan Feltner (0-0, 0.00 ERA), while the Astros have opted for Cody Bolton (0-0, 3.00 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Astros as the most likely winner of the Astros vs. Rockies game.

This article offers an expanded analysis of Monday's matchup, including best bets and picks.

Astros vs. Rockies prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the result of Monday's MLB game between the Astros and Rockies, forming part of our MLB predictions coverage.

Our famous predictive model gives the Astros a 58% chance of beating the Rockies.

According to our model, the Rockies (+1.5) have a 52% chance of covering the run line, while the over/under total of 10.5 runs has a 56% chance of going over.

Astros vs. Rockies odds [4/6/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Astros vs. Rockies picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: