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Tigers vs. Padres prediction: Detroit favored to win MLB Opening Day matchup [3/26/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Detroit Tigers vs San Diego Padres predictions for MLB Thursday.
The San Diego Padres will take on the Detroit Tigers on Opening Day of the 2022 MLB season at Petco Park on Thursday, beginning at 4:10 PM ET.
The Padres will have Nick Pivetta (0-0, 0.00 ERA) as their starting pitcher, while the Tigers have opted for Tarik Skubal (0-0, 0.00 ERA).
Based on the latest simulations, Dimers' refined MLB model gives the Tigers a slight edge with a 54% win probability over the Padres.
This article offers further insights into Thursday's Tigers vs. Padres matchup, including best bets and picks.
Tigers vs. Padres prediction: Who will win on MLB Opening Day?
Using trusted machine learning and data, we have simulated the result of Thursday's MLB game between the Tigers and Padres, forming part of our MLB predictions coverage.
Our leading predictive model gives the Tigers a 54% chance of beating the Padres.
According to our model, the Padres (+1.5) have a 60% chance of covering the run line, while the 7-run over/under has a 53% chance of going over.
Tigers vs. Padres odds [3/26/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Tigers | Padres |
|---|---|---|
| Run Line | -1.5 (+140) | +1.5 (-164) |
| Moneyline | -124 | +106 |
| Total | o7 (-106) | u7 (-108) |
All odds are correct at the time of publication and are subject to change.
Tigers vs. Padres picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Padres +1.5 | -164 |
| Moneyline | Tigers | -124 |
| Total | Over 7 | -106 |
According to our MLB best bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Tigers vs. Padres game-day updates and essential details
Thursday's MLB game between the Padres and Tigers at Petco Park is scheduled to commence at 4:10 PM ET.
- Who: Detroit Tigers vs. San Diego Padres
- Date: Thursday, March 26, 2026
- Time: 4:10 PM ET/1:10PM PT
- Venue: Petco Park
Conclusion
We predict the Tigers, with a 54% win probability, will likely beat the Padres on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Tigers vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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