College football picks today: Week 12 Wednesday best bets include Buffalo vs. Central Michigan play [11/12/2025]

Today’s college football picks for November 12, 2025 are here, with Buffalo vs. Central Michigan and Northern Illinois vs. Massachusetts among the top plays identified by our model across Wednesday’s college football play.

Dimers’ predictive analytics engine runs 24/7, scanning the latest football odds to discover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [11/12, updated 6:32PM ET]

Below, you’ll find today’s best college football bets, ranked by edge for Wednesday, November 12, 2025.

Central Michigan ML (-126)

• Edge: 3.4%
• Probability: 59.1%
• Matchup: Buffalo vs. Central Michigan (7:00PM ET, Wednesday)

Our model has identified value on Central Michigan to defeat Buffalo at -126 odds. A 59.1% probability produces an edge of 3.4%, making this the strongest play for today's college football slate.

Northern Illinois vs. Massachusetts under 43.5 points (-110)

• Edge: 3.3%
• Probability: 55.7%
• Matchup: Northern Illinois vs. Massachusetts (7:00PM ET, Wednesday)

Northern Illinois vs. Massachusetts under 43.5 points carries a 3.3% edge and a probability of 55.7% at -110 odds, according to our model.

Miami Ohio ML (+185)

• Edge: 2.3%
• Probability: 37.4%
• Matchup: Toledo vs. Miami Ohio (7:00PM ET, Wednesday)

Miami Ohio ML at +185 odds shows a 2.3% edge, supported by a 37.4% probability in simulations.

Buffalo vs. Central Michigan under 44.5 points (-105)

• Edge: 2.2%
• Probability: 53.4%
• Matchup: Buffalo vs. Central Michigan (7:00PM ET, Wednesday)

A 2.2% edge and 53.4% probability make Buffalo vs. Central Michigan under 44.5 points at a value play in the Buffalo vs. Central Michigan matchup, per our model.

NCAAF best bets summary: Wednesday, 11/12/2025

As of 6:32PM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Buffalo vs. Central Michigan (7:00PM ET, Wednesday)
• Toledo vs. Miami Ohio (7:00PM ET, Wednesday)
• Northern Illinois vs. Massachusetts (7:00PM ET, Wednesday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for November 12, 2025, featuring plays such as Central Michigan ML and under 43.5 points in the Northern Illinois vs. Massachusetts matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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