College football picks today: Week 10 Wednesday best bets include two spread plays [10/29/2025]

Today’s college football picks for October 29, 2025 are here, with Jacksonville State vs. Middle Tennessee among the top plays identified by our model across Wednesday’s college football action.

Dimers’ predictive analytics engine runs 24/7, scanning the latest football odds to uncover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [10/29, updated 6:34AM ET]

Below, you’ll find today’s best college football bets, ranked by edge for Wednesday, October 29, 2025.

Middle Tennessee ML (+170)

• Edge: 11.9%
• Probability: 48.9%
• Matchup: Jacksonville State vs. Middle Tennessee (7:30PM ET, Wednesday)

Our model has identified value on Middle Tennessee to defeat Jacksonville State at +170 odds. A 48.9% probability produces an edge of 11.9%, making this the strongest play for today's college football slate.

Middle Tennessee +4 (-108)

• Edge: 11.7%
• Probability: 63.6%
• Matchup: Jacksonville State vs. Middle Tennessee (7:30PM ET, Wednesday)

Middle Tennessee +4 carries a 11.7% edge and a probability of 63.6% at -108 odds, according to our model.

Florida International +3.5 vs. Missouri State(-114)

• Edge: 2.8%
• Probability: 56.1%
• Matchup: Florida International vs. Missouri State (8:00PM ET, Wednesday)

Florida International +3.5 vs. Missouri State at -114 odds shows a 2.8% edge, supported by a 56.1% probability in simulations.

NCAAF best bets summary: Wednesday, 10/29/2025

As of 6:34AM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Jacksonville State vs. Middle Tennessee (7:30PM ET, Wednesday)
• Florida International vs. Missouri State (8:00PM ET, Wednesday)
• Norfolk State vs. Delaware State (7:00PM ET, Thursday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for October 29, 2025, featuring plays such as Middle Tennessee ML and Middle Tennessee +4. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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