College football picks today: Week 17 Saturday best bets include Tulane vs. Mississippi play [12/20/2025]

Tulane vs. Mississippi over 57.5 points (-110)

• Edge: 5.2%
• Probability: 57.6%
• Matchup: Tulane vs. Mississippi (3:30PM ET, Saturday)

Our model has identified value on over 57.5 points in Tulane vs. Mississippi at -110 odds. A 57.6% probability produces an edge of 5.2%, making this the strongest play for today's college football slate.

Illinois State vs. Villanova over 51.5 points (-106)

• Edge: 4.5%
• Probability: 56%
• Matchup: Illinois State vs. Villanova (7:30PM ET, Saturday)

Illinois State vs. Villanova over 51.5 points carries a 4.5% edge and a probability of 56% at -106 odds, according to our model.

Texas A&M -3.5 (-102)

• Edge: 4.0%
• Probability: 54.5%
• Matchup: Miami Florida vs. Texas A&M (12:00PM ET, Saturday)

Texas A&M -3.5 vs. Miami Florida at -102 odds shows a 4.0% edge, supported by a 54.5% probability in simulations.

Texas A&M ML (-155)

• Edge: 3.8%
• Probability: 64.6%
• Matchup: Miami Florida vs. Texas A&M (12:00PM ET, Saturday)

A 3.8% edge and 64.6% probability make Texas A&M at the moneyline at a value play in the Miami Florida vs. Texas A&M matchup, per our model.

Montana ML (+170)

• Edge: 3.3%
• Probability: 40.4%
• Matchup: Montana vs. Montana State (4:00PM ET, Saturday)

Montana ML at +170 odds presents a 3.3% edge, with simulations resulting in a probability of 40.4%.

Montana +5.5 (-110)

• Edge: 2.1%
• Probability: 54.5%
• Matchup: Montana vs. Montana State (4:00PM ET, Saturday)

Our model finds value on Montana +5.5 at -110 odds, supported by an edge of 2.1%.

Miami Florida vs. Texas A&M under 48.5 points (-115)

• Edge: 2.1%
• Probability: 55.6%
• Matchup: Miami Florida vs. Texas A&M (12:00PM ET, Saturday)

Our model has uncovered value on Miami Florida vs. Texas A&M under 48.5 points at -115 odds. A 55.6% probability produces a 2.1% edge, making this a strong play for today's college football action.

NCAAF best bets summary: Saturday, 12/20/2025

As of 2:04AM ET, here are our top college football bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Tulane vs. Mississippi	Over 57.5 Points	-110 @ BetMGM	5.2%	57.6%
Illinois State vs. Villanova	Over 51.5 Points	-106 @ FanDuel	4.5%	56%
Miami Florida vs. Texas A&M	Texas A&M -3.5	-102 @ FanDuel	4.0%	54.5%
Miami Florida vs. Texas A&M	Texas A&M ML	-155 @ DraftKings	3.8%	64.6%
Montana vs. Montana State	Montana ML	+170 @ BetMGM	3.3%	40.4%
Montana vs. Montana State	Montana +5.5	-110 @ BetMGM	2.1%	54.5%
Miami Florida vs. Texas A&M	Under 48.5 Points	-115 @ DraftKings	2.1%	55.6%

List of upcoming college football games to bet on now

• Miami Florida vs. Texas A&M (12:00PM ET, Saturday)
• Tulane vs. Mississippi (3:30PM ET, Saturday)
• Montana vs. Montana State (4:00PM ET, Saturday)
• James Madison vs. Oregon (7:30PM ET, Saturday)
• Illinois State vs. Villanova (7:30PM ET, Saturday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for December 20, 2025, featuring plays such as over 57.5 points in the Tulane vs. Mississippi matchup and over 51.5 points in the Illinois State vs. Villanova matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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