College football picks today: Week 13 Saturday best bets include San Jose State vs. San Diego State play [11/22/2025]

Today’s college football picks for November 22, 2025 are here, with San Jose State vs. San Diego State among the top plays identified by our model across Saturday’s college football action.

Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to find legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [11/22, updated 10:07PM ET]

Below, you’ll find today’s best college football bets, ranked by edge for Saturday, November 22, 2025.

San Jose State ML (+310)

• Edge: 2.9%
• Probability: 27.3%
• Matchup: San Jose State vs. San Diego State (10:30PM ET, Saturday)

Our model has identified value on San Jose State to defeat San Diego State at +310 odds. A 27.3% probability produces an edge of 2.9%, making this the strongest play for today's college football slate.

San Jose State +10.5 (-110)

• Edge: 2.2%
• Probability: 54.6%
• Matchup: San Jose State vs. San Diego State (10:30PM ET, Saturday)

San Jose State +10.5 carries a 2.2% edge and a probability of 54.6% at -110 odds, according to our model.

NCAAF best bets summary: Saturday, 11/22/2025

As of 10:07PM ET, here are our top college football bets by edge recommended by our model:

List of upcoming college football games to bet on now

• Utah State vs. Fresno State (10:30PM ET, Saturday)
• San Jose State vs. San Diego State (10:30PM ET, Saturday)
• Washington vs. UCLA (10:30PM ET, Saturday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for November 22, 2025, featuring plays such as San Jose State ML and San Jose State +10.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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