College football picks today: Week 11 Friday best bets include two moneyline plays [11/7/2025]

Today’s college football picks for November 7, 2025 are here, with Northwestern vs. Southern California and Tulane vs. Memphis among the top plays identified by our model across Friday’s college football schedule.

Dimers’ predictive analytics engine runs 24/7, scanning the latest football odds to uncover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [11/7, updated 8:32PM ET]

Below, you’ll find today’s best college football bets, ranked by edge for Friday, November 7, 2025.

Northwestern vs. Southern California over 53.5 points (-105)

• Edge: 7.0%
• Probability: 58.2%
• Matchup: Northwestern vs. Southern California (9:00PM ET, Friday)

Our model has identified value on over 53.5 points in Northwestern vs. Southern California at -105 odds. A 58.2% probability produces an edge of 7.0%, making this the strongest play for today's college football slate.

Memphis ML (-148)

• Edge: 3.1%
• Probability: 62.8%
• Matchup: Tulane vs. Memphis (9:00PM ET, Friday)

Memphis ML carries a 3.1% edge and a probability of 62.8% at -148 odds, according to our model.

Northwestern ML (+490)

• Edge: 2.9%
• Probability: 19.9%
• Matchup: Northwestern vs. Southern California (9:00PM ET, Friday)

Northwestern ML at +490 odds shows a 2.9% edge, supported by a 19.9% probability in simulations.

Iowa State ML (+240)

• Edge: 9.0%
• Probability: 38.5%
• Matchup: Iowa State vs. TCU (3:30PM ET, Saturday)

A 9.0% edge and 38.5% probability make Iowa State at the moneyline at a value play in the Iowa State vs. TCU matchup, per our model.

Air Force ML (+185)

• Edge: 8.3%
• Probability: 43.4%
• Matchup: Air Force vs. San Jose State (6:00PM ET, Saturday)

Air Force ML at +185 odds presents a 8.3% edge, with simulations resulting in a probability of 43.4%.

NCAAF best bets summary: Friday, 11/7/2025

As of 8:32PM ET, here are our top college football bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Northwestern vs. Southern California	Over 53.5 Points	-105 @ FanDuel	7.0%	58.2%
Tulane vs. Memphis	Memphis ML	-148 @ DraftKings	3.1%	62.8%
Northwestern vs. Southern California	Northwestern ML	+490 @ DraftKings	2.9%	19.9%
Iowa State vs. TCU	Iowa State ML	+240 @ BetMGM	9.0%	38.5%
Air Force vs. San Jose State	Air Force ML	+185 @ BetMGM	8.3%	43.4%

List of upcoming college football games to bet on now

• Tulane vs. Memphis (9:00PM ET, Friday)
• Northwestern vs. Southern California (9:00PM ET, Friday)
• Indiana vs. Penn State (12:00PM ET, Saturday)
• Brigham Young vs. Texas Tech (12:00PM ET, Saturday)
• Georgia vs. Mississippi State (12:00PM ET, Saturday)
• Colorado vs. West Virginia (12:00PM ET, Saturday)
• Southern Methodist vs. Boston College (12:00PM ET, Saturday)
• Temple vs. Army (12:00PM ET, Saturday)
• James Madison vs. Marshall (12:00PM ET, Saturday)
• Southern Miss vs. Arkansas State (12:00PM ET, Saturday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for November 7, 2025, featuring plays such as over 53.5 points in the Northwestern vs. Southern California matchup and Memphis ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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