Guardians vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [4/15/2026]

The St. Louis Cardinals will take on the Cleveland Guardians, in what is expected to be a close MLB game, at Busch Stadium on Wednesday, commencing at 1:15 PM ET.

The Cardinals will start Dustin May (1-2, 9.45 ERA), up against Slade Cecconi (0-2, 5.74 ERA) for the Guardians.

Based on the latest simulation results, Dimers' advanced MLB model gives the Cardinals a slight edge with a 51% win probability over the Guardians.

This article offers a closer look at Wednesday's Guardians vs. Cardinals matchup, including best bets and picks.

Guardians vs. Cardinals prediction: Who will win?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB matchup between the Guardians and Cardinals, forming part of our MLB predictions coverage.

Our leading predictive model gives the Cardinals a 51% chance of beating the Guardians.

According to our model, the over/under total of 8.5 runs has a 51% chance of going over.

Guardians vs. Cardinals odds [4/15/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Guardians vs. Cardinals picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: