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Guardians vs. Cardinals prediction: Tight battle projected in updated analysis for Monday's MLB matchup [4/13/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Cleveland Guardians vs St. Louis Cardinals predictions for MLB Monday.
MLB action continues on Monday at 7:45 PM ET as the Cleveland Guardians lock horns with the St. Louis Cardinals at Busch Stadium.
Matthew Liberatore (0-0, 3.38 ERA) will be on the bump for the Cardinals, while the Guardians have opted for Gavin Williams (1-1, 2.04 ERA).
Based on the latest simulations, Dimers' advanced MLB model gives an equal chance for both both teams to win the Guardians-Cardinals matchup.
This article offers further insights into Monday's Guardians vs. Cardinals matchup, including best bets and picks.
Guardians vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Guardians and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model can't split the two teams, giving both the Guardians and Cardinals a 50% chance of winning the game.
According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.
Guardians vs. Cardinals odds [4/13/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Cardinals |
|---|---|---|
| Run Line | -1.5 (+140) | +1.5 (-165) |
| Moneyline | -115 | +105 |
| Total | o8 (-112) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Guardians vs. Cardinals picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -165 |
| Moneyline | Cardinals | +105 |
| Total | Over 8 | -112 |
According to our MLB best bets, the top play to make on this game is Cardinals to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Guardians vs. Cardinals game-day updates and essential details
Monday's MLB game between the Cardinals and Guardians at Busch Stadium is scheduled to begin at 7:45 PM ET.
- Who: Cleveland Guardians vs. St. Louis Cardinals
- Date: Monday, April 13, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict a close game between the Guardians and Cardinals on Monday, with each team having a 50% chance of winning.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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