Butler vs. San Diego prediction: San Diego favored to win in college football Week 12, 2025

San Diego will square off with Butler in Week 12 college football action at Torero Stadium on Saturday, starting at 4:00PM ET.

Based on updated simulations, Dimers' proven college football model projects San Diego as the most likely winner of the Butler vs. San Diego game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Butler vs. San Diego prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Butler vs. San Diego 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives San Diego a 62% chance of beating Butler. Our predicted final score has San Diego winning 25-21.

According to our model, Butler (+7.5) has a 60% chance of covering the spread, while the 47.5-point over/under has a 52% chance of staying under.

Butler vs. San Diego odds

We have researched the best College Football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Butler vs. San Diego picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Butler to win.

Butler vs. San Diego game-day updates and essential details

Saturday's college football game between San Diego and Butler at Torero Stadium is scheduled to begin at 4:00PM ET.

• Who: Butler vs. San Diego
• Date: Saturday, November 15, 2025
• Time: 4:00PM ET/1:00PM PT
• Venue: Torero Stadium

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Conclusion

We predict San Diego, with a 62% win probability, will likely beat Butler on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Butler vs. San Diego insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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