Buffalo vs. Central Michigan prediction: Why Central Michigan is favored to win in college football Week 12, 2025

Central Michigan will take on Buffalo in Week 12 college football action at Kelly/Shorts Stadium on Wednesday, with kickoff at 7:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects Central Michigan as the most likely winner of the Buffalo vs. Central Michigan game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Buffalo vs. Central Michigan prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Buffalo vs. Central Michigan 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Central Michigan a 59% chance of beating Buffalo. Our predicted final score has Central Michigan winning 24-21.

According to our model, the bookmakers have got it right, and Buffalo and Central Michigan each have a 50% chance of covering the spread, while the over/under total of 44.5 points has a 53% chance of staying under.

Buffalo vs. Central Michigan odds

We have sourced the best College Football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Buffalo vs. Central Michigan picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Under 44.5 total points.

Buffalo vs. Central Michigan game-day updates and essential details

Wednesday's college football action between Central Michigan and Buffalo at Kelly/Shorts Stadium is scheduled to begin at 7:00PM ET.

• Who: Buffalo vs. Central Michigan
• Date: Wednesday, November 12, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Kelly/Shorts Stadium

Conclusion

We predict Central Michigan, with a 59% win probability, will likely beat Buffalo on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Buffalo vs. Central Michigan insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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