Arizona State vs. Iowa State prediction: Why Iowa State is favored to win in college football Week 10, 2025

Iowa State will take on Arizona State in Week 10 college football action at Jack Trice Stadium on Saturday, with kickoff at 1:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts the Iowa State as the most likely winner of the Arizona State vs. Iowa State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Arizona State vs. Iowa State prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of Arizona State vs. Iowa State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives Iowa State a 63% chance of defeating Arizona State. Our predicted final score has Iowa State winning 27-22.

According to our model, Arizona State (+7.5) has a 60% chance of covering the spread, while the 48.5-point over/under has a 52% chance of staying under.

Arizona State vs. Iowa State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Arizona State	Iowa State
Spread	+7.5 (-108)	-7.5 (-110)
Moneyline	+245	-290
Total	o48.5 (-105)	u48.5 (-110)

All odds are correct at the time of publication and are subject to change.

Arizona State vs. Iowa State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Arizona State +7.5	-108
Moneyline	Arizona State	+245
Total	Under 48.5	-110

According to our college football best bets, the top play to make on this game is Arizona State to win.

Arizona State vs. Iowa State game-day updates and essential details

Saturday's college football action between Iowa State and Arizona State at Jack Trice Stadium is scheduled to begin at 1:00PM ET.

• Who: Arizona State vs. Iowa State
• Date: Saturday, November 1, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Jack Trice Stadium

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's massive day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Iowa State, with a 63% win probability, will likely beat Arizona State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Arizona State vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay informed with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most accurate projections for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.