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Arizona State vs. Duke prediction: Duke favored to win in college football Week 19 [2025]

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Written by Mac Douglass

Get Arizona State vs Duke predictions for college football Wednesday.

Arizona State-Duke Predictions and Game Preview.
Arizona State vs. Duke college football gameday prediction for Wednesday, December 31, 2025.

Duke will take on Arizona State in Week 19 college football action at Sun Bowl on Wednesday, with kickoff at 2:00 PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Duke as the most likely winner of the Arizona State vs. Duke game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Arizona State vs. Duke prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Arizona State vs. Duke 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Duke a 57% chance of defeating Arizona State. Our predicted final score has Duke winning 26-23.

According to our model, Arizona State (+4.5) has a 60% chance of covering the spread, while the 49.5-point over/under has an equal 50-50 chance of hitting.

 

Arizona State vs. Duke odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type Arizona State Duke
Spread +4.5 (-110) -4.5 (-110)
Moneyline +160 -180
Total o49.5 (-105) u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

Arizona State vs. Duke picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Arizona State +4.5 -110
Moneyline Arizona State +160
Total Over 49.5 -105

According to our college football best bets, the top play to make on this game is Arizona State +4.5 at the spread.

 

Arizona State vs. Duke game-day updates and essential details

Wednesday's college football action between Duke and Arizona State at Sun Bowl is scheduled to begin at 2:00 PM ET.

  • Who: Arizona State vs. Duke
  • Date: Wednesday, December 31, 2025
  • Time: 2:00 PM ET/11:00AM PT
  • Venue: Sun Bowl

Conclusion

We predict Duke, with a 57% win probability, will likely beat Arizona State on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Arizona State vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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