Arizona State vs. Duke prediction: Duke favored to win in college football Week 19 [2025]

Duke and Arizona State will meet in Week 19 college football action at Sun Bowl on Wednesday, commencing at 2:00 PM ET.

Based on the latest simulations, Dimers' advanced college football model projects Duke as the most likely winner of the Arizona State vs. Duke game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Arizona State vs. Duke prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Arizona State vs. Duke 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Duke a 57% chance of defeating Arizona State. Our predicted final score has Duke winning 25-22.

According to our model, Arizona State (+3.5) has a 56% chance of covering the spread, while the over/under total of 47.5 points has a 53% chance of staying under.

Arizona State vs. Duke odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Arizona State vs. Duke picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: