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76ers vs. Knicks prediction: New York favored to win Game 2 [2026 NBA Playoffs]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Philadelphia 76ers vs New York Knicks predictions for NBA Playoffs Wednesday.
The New York Knicks will take on the Philadelphia 76ers in Game 2 of their 2026 NBA Playoffs series at Madison Square Garden on Wednesday, beginning at 7:00 PM ET.
Based on the latest simulation results and today’s injury news, Dimers' advanced NBA model predicts the Knicks as the most likely winner of the 76ers vs. Knicks Game 2 matchup.
This prediction follows the latest NBA Injury Report, which suggests the Knicks lineup will feature players like Jalen Brunson, OG Anunoby and Karl-Anthony Towns, while the 76ers will look to Joel Embiid, Tyrese Maxey and Paul George.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Sixers vs. Sixers prediction: Who will win Game 2?
Using powerful machine learning and data analysis, we have simulated the result of Wednesday's NBA Playoffs game between the 76ers and Knicks, forming part of our NBA predictions coverage.
Our leading predictive model currently gives the Knicks a 72% chance of beating the 76ers in Game 2 of the series. Our predicted final score has the Knicks winning 111-105.
According to our model, the 76ers (+7.5) have a 53% chance of covering the spread, while the over/under total of 216.5 points has an equal 50-50 chance of hitting.
76ers vs. Knicks Game 2 odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Knicks |
|---|---|---|
| Spread | +7.5 (-106) | -7.5 (-110) |
| Moneyline | +245 | -295 |
| Total | o216.5 (-110) | u216.5 (-108) |
All odds are correct at the time of publication and are subject to change.
76ers vs. Knicks picks and best bet for Game 2
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | 76ers +7.5 | -106 |
| Moneyline | Knicks | -295 |
| Total | Over 216.5 | -110 |
According to our NBA best bets, the top play to make on this game is 76ers +7.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
76ers vs. Knicks Game 2 player props
NBA prop bets are an exciting way to wager on Wednesday's 76ers vs. Knicks game without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Madison Square Garden.
Joel Embiid is expected to lead the 76ers with 26 points, 8 rebounds and 5 assists, while Jalen Brunson is projected to have 25 points, 3 rebounds and 7 assists for the Knicks.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and today's NBA first basket picks.
76ers prediction
Our model's projected player stats for the 76ers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Joel Embiid | 26 | 8 | 5 | 2 | 48 |
| Tyrese Maxey | 25 | 4 | 6 | 3 | 47 |
| Paul George | 18 | 6 | 4 | 3 | 38 |
| VJ Edgecombe | 15 | 6 | 4 | 2 | 33 |
| Kelly Oubre | 12 | 6 | 2 | 1 | 27 |
Knicks prediction
Projected points, rebounds, assists and three-pointers made for the Knicks:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Jalen Brunson | 25 | 3 | 7 | 3 | 44 |
| OG Anunoby | 20 | 6 | 3 | 3 | 39 |
| K. Towns | 19 | 12 | 4 | 2 | 47 |
| Mikal Bridges | 13 | 3 | 3 | 2 | 26 |
| Josh Hart | 13 | 9 | 6 | 2 | 37 |
Sixers vs. Knicks Game 2 updates and essential details
Wednesday's Game 2 between the Knicks and 76ers in the NBA Playoffs is scheduled to commence at 7:00 PM ET.
- Who: Philadelphia 76ers vs. New York Knicks
- Date: Wednesday, May 6, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Madison Square Garden
- NBA Playoffs bracket: Updated NBA Playoffs bracket and schedule
The NBA Playoffs is an annual elimination tournament held to decide the league's champion.
Sixteen teams, including the 76ers and Knicks, reached the 2026 NBA Playoffs, which includes four rounds: the First Round, Conference Semifinals, Conference Finals, and NBA Finals.
Each round is played as a best-of-seven series, with the first team to four wins advancing to the next round until a champion is crowned.
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Conclusion
We predict the Knicks, with a 72% win probability, will likely beat the 76ers in Wednesday's NBA playoffs matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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