Guardians vs. White Sox Prediction and Odds - Sep 22, 2022

The Chicago White Sox face the Cleveland Guardians in MLB action at Guaranteed Rate Field on Thursday, starting at 8:10PM ET.

Johnny Cueto (7-8, 3.09 ERA) will be on the bump for the White Sox, pitting him against Shane Bieber (11-8, 2.83 ERA) for the Guardians.

Dimers' best betting picks for Guardians vs. White Sox, plus game predictions and betting odds, are featured in this article.


Who will win Guardians vs. White Sox?

Using cutting-edge machine learning and data, has simulated Thursday's Guardians-White Sox MLB game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Guardians a 55% chance of getting the W against the White Sox.

More: Guardians vs. White Sox Simulated 10,000 Times

Guardians vs. White Sox Odds

  • Run Line: White Sox +1.5 (-140), Guardians -1.5 (+120)
  • Moneyline: White Sox +135, Guardians -145
  • Total: Over/Under 7 (-105/+100)

Run Line, Moneyline and Over/Under

The White Sox are listed as +1.5 underdogs against the Guardians, with -140 at DraftKings Sportsbook the best odds currently available.

For the favored Guardians (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +120.

DraftKings Sportsbook currently has the best moneyline odds for the White Sox at +135. That means you can bet $100 to profit $135, earning a total payout of $235, if they win.

Meanwhile, BetMGM currently has the best moneyline odds for the Guardians at -145, where you can risk $145 to win $100, for a total payout of $245, if they come out on top.

The Over/Under for total runs scored sits at 7 with Caesars Sportsbook, which currently has the best odds for the Over at -105, while BetMGM currently has the best odds for the Under at +100.

As always, check out all the legal sportbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 59% chance of covering the run line, while the Over/Under total of 7 runs is a 59% chance of going Over.

More: Best Prop Bets Today

Best Bets for Guardians vs. White Sox


When you see a 🔥, you know you've found one of our best free picks today across all sports.

Dimers' best bets are based on complex modeling and gambling intelligence to help you make better investments with your state's legal sportsbooks.

While the Guardians are more likely to win the game, according to DimersBOT, taking the White Sox moneyline is the best option due to the 2.5% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on is one of the keys to achieving long-term profitability.

Guardians vs. White Sox Prediction

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Dimers has full betting coverage of Thursday's Guardians-White Sox matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates often, so refresh this article for any changes to our betting analysis before Guardians vs. White Sox on Thursday September 22, 2022.


Guardians vs. White Sox 2022 Game Info

Thursday's matchup between the White Sox and Guardians at Guaranteed Rate Field is scheduled to begin at 8:10PM ET.

  • Who: Cleveland Guardians vs. Chicago White Sox
  • Date: Thursday September 22, 2022
  • Time: 8:10PM ET / 5:10PM PT
  • Venue: Guaranteed Rate Field

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What MLB games are on today?

Now you've got the 411 on Guardians vs. White Sox, take a look at the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.

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