Giants vs. Diamondbacks Prediction and Odds - Sep 23, 2022

MLB action continues on Friday at 9:40PM ET as the San Francisco Giants lock horns with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will send Tommy Henry (3-4, 5.50 ERA) to the mound, pitting him against Carlos Rodón (13-8, 2.84 ERA) for the Giants.

Dimers' top betting picks for Giants vs. Diamondbacks, plus game predictions and betting odds, are featured below.


Who will win Giants vs. Diamondbacks?

Using trusted machine learning and data, has simulated Friday's Giants-Diamondbacks MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Giants a 57% chance of defeating the Diamondbacks.

More: Giants vs. Diamondbacks Simulated 10,000 Times

Giants vs. Diamondbacks Odds

  • Run Line: Diamondbacks +1.5 (-111), Giants -1.5 (-105)
  • Moneyline: Diamondbacks +152, Giants -175
  • Total: Over/Under 8 (-115/+100)

Run Line, Moneyline and Over/Under

The Diamondbacks are currently +1.5 underdogs against the Giants, with -111 at FanDuel Sportsbook the best odds currently available.

For the favored Giants (-1.5) to cover the run line, BetMGM has the best odds currently on offer at -105.

FanDuel Sportsbook currently has the best moneyline odds for the Diamondbacks at +152. That means you can throw down $100 to profit $152, earning a total payout of $252, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Giants at -175, where you can risk $175 to win $100, for a total payout of $275, if they come out on top.

The Over/Under for total runs scored sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while BetMGM currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Diamondbacks (+1.5) are a 54% chance of covering the run line, while the 8-run Over/Under is a 56% chance of going Over.

More: Track Your Bets via Dimers' Bet Center

Best Bets for Giants vs. Diamondbacks


Our best bets are based on world-class simulations and betting expertise to bring you the best possible plays every day of the year.

While the Giants are more likely to win the game, according to DimersBOT, betting on the Diamondbacks moneyline is the best option because of the 3.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers is pivotal to achieving long-term profitability as a bettor.

Giants vs. Diamondbacks Prediction

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Dimers has full betting coverage of Friday's Giants-Diamondbacks matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep checking this article for the latest betting analysis before Giants vs. Diamondbacks on Friday September 23, 2022.


Giants vs. Diamondbacks 2022 Game Info

Friday's matchup between the Diamondbacks and Giants at Chase Field is scheduled to begin at 9:40PM ET.

  • Who: San Francisco Giants vs. Arizona Diamondbacks
  • Date: Friday September 23, 2022
  • Time: 9:40PM ET / 6:40PM PT
  • Venue: Chase Field

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Want more MLB predictions like this?

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We use the power of predictive analytics to find value in the markets so we can write the best MLB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.

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