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Cubs vs. Pirates Prediction and Odds - Sep 23, 2022

The Pittsburgh Pirates take on the Chicago Cubs in MLB action at PNC Park on Friday, beginning at 6:35PM ET.

Bryse Wilson (3-9, 6.07 ERA) will start on the mound for the Pirates, up against Javier Assad (1-2, 3.86 ERA) for the Cubs.

Dimers' free betting picks for Cubs vs. Pirates, plus game predictions and betting odds, are featured in this article.


Who will win Cubs vs. Pirates?

Based on cutting-edge machine learning and data, Dimers.com has simulated Friday's Cubs-Pirates MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently can't split the two teams, giving both the Cubs and Pirates a 50% chance of winning the game.

More: Cubs vs. Pirates Simulated 10K Times

Cubs vs. Pirates Current Odds

  • Run Line: Pirates +1.5 (-205), Cubs -1.5 (+168)
  • Moneyline: Pirates -120, Cubs +105
  • Total: Over/Under 8 (-114/+100)

Run Line, Moneyline and Over/Under

The Pirates are listed as +1.5 underdogs versus the Cubs, with -205 at FanDuel Sportsbook the best odds currently available.

For the favored Cubs (-1.5) to cover the run line, FanDuel Sportsbook also has the best odds currently on offer at +168.

Caesars Sportsbook currently has the best moneyline odds for the Pirates at -120. That means you can risk $120 to win $100, for a total payout of $220, if they get the W.

On the other hand, BetMGM currently has the best moneyline odds for the Cubs at +105, where you can bet $100 to profit $105, earning a total payout of $205, if they win.

The Over/Under for total runs scored is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while Caesars Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 65% chance of covering the run line, while the Over/Under total of 8 runs is a 52% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Cubs vs. Pirates


Our best bets are based on complex modeling and gambling intelligence to help you make more informed investments with the legal sportsbooks in the United States.

Even though the Pirates are more likely to cover the run line, our best bet of Cubs -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

Cubs vs. Pirates Probabilities

Click or tap on See Matchup to reveal more.


Dimers has full coverage of Friday's Cubs-Pirates matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this article for any changes to our betting insights ahead of Cubs vs. Pirates on Friday September 23, 2022.


Cubs vs. Pirates 2022 Game Info

Friday's matchup between the Pirates and Cubs at PNC Park is scheduled to begin at 6:35PM ET.

  • Who: Chicago Cubs vs. Pittsburgh Pirates
  • Date: Friday September 23, 2022
  • Time: 6:35PM ET / 3:35PM PT
  • Venue: PNC Park

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Want more MLB analysis like this?

So, you liked our Cubs vs. Pirates betting analysis? Awesome. Did you know our MLB Betting News section has a detailed betting preview for every MLB game the second the sportsbooks release their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets, which allows us to create the most authoritative MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds on the market.

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