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Bills vs. Lions Week 12 Prediction and Odds - Nov 24, 2022

The Detroit Lions take on the Buffalo Bills in NFL Week 12 action at Ford Field on Thanksgiving Day, starting at 12:30PM ET.

Dimers' best betting picks for Bills vs. Lions, plus game predictions, betting odds and projected player stats, are featured below.


Who will win Bills vs. Lions?

Based on cutting-edge machine learning and data, Dimers.com has simulated Thursday's Bills-Lions NFL game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Bills a 77% chance of winning against the Lions in Week 12 of the NFL season.

More: Full Betting Guide for Bills vs. Lions

Bills vs. Lions Game Odds

  • Spread: Lions +9.5 (-105), Bills -9.5 (-110)
  • Moneyline: Lions +350, Bills -410
  • Total: Over/Under 54.5 (-110/-110)

Point Spread, Moneyline and Over/Under

The Lions are +9.5 underdogs versus the Bills, with -105 at PointsBet the best odds currently available.

For the favored Bills (-9.5) to cover the spread, Caesars Sportsbook has the best odds currently on offer at -110.

BetMGM currently has the best moneyline odds for the Lions at +350. That means you can bet $100 to profit $350, earning a total payout of $450, if they win.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Bills at -410, where you can risk $410 to win $100, for a total payout of $510, if they come out on top.

The Over/Under for total points scored is set at 54.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best NFL odds and lines.

According to DimersBOT, the Lions (+9.5) are a 53% chance of covering the spread, while the 54.5-point Over/Under is a 53% chance of going Under.

More: Best Prop Bets Today

Best Bets for Bills vs. Lions

  • Spread: Lions +9.5 @ -105 via PointsBet (53% probability)
  • Moneyline: Lions @ +350 via BetMGM (0.9% edge)
  • Total: Under 54.5 @ -110 via Caesars Sportsbook (53% probability)


Our best bets are based on detailed modeling and gambling expertise to help you make better decisions with the legal sportsbooks in the United States.

While the Bills are more likely to win the game, according to DimersBOT, taking the Lions moneyline is the best option due to the edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is crucial to being a profitable bettor in the long run.

Bills vs. Lions Prediction

Dimers.com's predicted final score for Buffalo vs. Detroit at Ford Field in Week 12 has the Bills winning 31-22.

Click or tap on See Matchup for more.


Dimers has full betting coverage of this week's Bills-Lions matchup in Week 12, including pregame predictions, top betting picks, and live scores.

Bills vs. Lions Player Props

Who will score an anytime touchdown in Bills vs. Lions? The latest data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Bills and Lions, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you choose the best prop bets for Thursday's game.

According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first TD in Bills vs. Lions.

DimersBOT gives Diggs a 13.5% chance of getting in for six first at Ford Field, while the Bills WR is a 59.7% chance of registering an anytime touchdown.

Scroll down for our complete list of first and anytime TD scorer probabilities.


First Touchdown Scorer Probabilities

Buffalo Bills

  • Stefon Diggs: 13.5% probability
  • Gabe Davis: 9.4% probability
  • Josh Allen: 8.2% probability
  • Devin Singletary: 7.5% probability
  • Dawson Knox: 6.1% probability

Detroit Lions

  • Jamaal Williams: 10.6% probability
  • Amon-Ra St. Brown: 5.7% probability
  • D'Andre Swift: 4.6% probability
  • Josh Reynolds: 4.3% probability
  • Justin Jackson: 3.7% probability

Anytime Touchdown Scorer Probabilities

Buffalo Bills

  • Stefon Diggs: 59.7% probability
  • Gabe Davis: 45.3% probability
  • Josh Allen: 41.4% probability
  • Devin Singletary: 37.0% probability
  • Dawson Knox: 32.3% probability

Detroit Lions

  • Jamaal Williams: 52.3% probability
  • Amon-Ra St. Brown: 31.0% probability
  • D'Andre Swift: 26.0% probability
  • Josh Reynolds: 24.7% probability
  • Justin Jackson: 20.4% probability

Bills-Lions Projected Player Stats

Of the starting quarterbacks, the Bills' Josh Allen is projected to have a big game with 285 passing yards. The Lions' Jared Goff is expected to throw for 252 yards.

Bills Starting QB

  • Josh Allen: 285 projected yards

Lions Starting QB

  • Jared Goff: 252 projected yards

Bills Rushing

  • Devin Singletary: 56 projected yards
  • Josh Allen: 43 projected yards
  • James Cook: 22 projected yards

Lions Rushing

  • Jamaal Williams: 59 projected yards
  • D'Andre Swift: 31 projected yards
  • Justin Jackson: 21 projected yards

Bills Receiving

  • Stefon Diggs: 100 projected yards
  • Gabe Davis: 65 projected yards
  • Dawson Knox: 39 projected yards
  • Isaiah McKenzie: 23 projected yards
  • Devin Singletary: 21 projected yards

Lions Receiving

  • Amon-Ra St. Brown: 80 projected yards
  • Kalif Raymond: 46 projected yards
  • DJ Chark: 36 projected yards
  • Josh Reynolds: 33 projected yards
  • D'Andre Swift: 22 projected yards

Remember, DimersBOT updates frequently, so check this page for any changes to our betting analysis before Bills vs. Lions on Thursday November 24, 2022.


Bills vs. Lions 2022

The NFL Week 12 matchup between the Lions and Bills at Ford Field is scheduled to start at 12:30PM ET.

  • Who: Buffalo Bills vs. Detroit Lions
  • Date: Thursday November 24, 2022
  • Time: 12:30PM ET / 9:30AM PT
  • Venue: Ford Field

Ready to join an online sportsbook and start betting on the NFL? Check out the best sports betting bonus offers in your state.

What other NFL games are on today?

The Bills and Lions aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every NFL game via our NFL Predictions section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!

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