Puebla vs. Santos Laguna prediction, odds, Liga MX picks [8/22/2026]

Using innovative machine learning and data, we have simulated the outcome of Saturday's Liga MX game between Puebla and Santos Laguna, forming part of our Liga MX predictions coverage.

Our famous predictive model indicates a 49.7% chance of Puebla winning, a 26.6% chance for Santos Laguna, and a 23.8% chance of a draw.

Additionally, the 2.5-goal over/under has a 55.8% chance of going over, with a 57.3% chance that both teams score.

Puebla vs. Santos Laguna odds

We have sourced the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Santos Laguna +230, Puebla +115

All odds are correct at the time of publication and are subject to change.

Puebla vs. Santos Laguna picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Puebla @ +115 via DraftKings
• Total Goals: Under 2.5 @ +125 via Bet365

According to our Liga MX best bets, the top play to make on this game is Puebla to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Puebla vs. Santos Laguna: Correct score and BTTS predictions

The top three most likely final scores, according to our model, are listed below, with a 1-1 draw being the most probable:

• Puebla 1-1 Santos Laguna (11.1% probability)
• Puebla 2-1 Santos Laguna (9.6%)
• Puebla 1-0 Santos Laguna (9.3%)

When it comes to the both teams to score (BTTS) market, we project a 57.3% chance of both sides finding the net and a 42.7% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, meaning the most likely correct score can differ from our predicted winner.

Puebla vs. Santos Laguna game-day updates and essential details

Saturday's game between Puebla and Santos Laguna is scheduled to begin at 9:00 PM ET.

• Who: Puebla vs. Santos Laguna
• Date: Saturday, August 22, 2026
• Time: 9:00 PM ET/6:00PM PT

Conclusion

According to our computer model, Puebla has a 49.7% win probability on Saturday, Santos Laguna has a 26.6% win probability, and there is a 23.8% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.