Club Tijuana vs. Santos Laguna prediction, odds, Liga MX picks [10/25/2026]

Using powerful machine learning and data analysis, we have re-simulated the outcome of Sunday's Liga MX matchup between Club Tijuana and Santos Laguna, forming part of our Liga MX predictions coverage.

Our independent predictive model indicates a 53.9% chance of Club Tijuana winning, a 23.5% chance for Santos Laguna, and a 22.5% chance of a draw. Additionally, the over/under total of 2.5 goals has a 58.6% chance of going over., with a 58.3% likelihood that both teams find the net.

Latest betting odds

We have researched the best Liga MX odds in America for this game, which are listed here:

• Moneyline: Santos Laguna +250, Club Tijuana +100
• Total Goals: Over/Under 2.5 (-158/+124)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Moneyline: Club Tijuana @ +100 via DraftKings
• Total Goals: Over 2.5 @ -158 via FanDuel

According to our Liga MX best bets, the top play to make on this game is Club Tijuana to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Correct score and BTTS projections

Here are the top three most likely final scores according to our model, with a 1-1 draw being the most probable:

• Club Tijuana 1-1 Santos Laguna (10.4% probability)
• Club Tijuana 2-1 Santos Laguna (9.8%)
• Club Tijuana 1-0 Santos Laguna (9%)

When it comes to the both teams to score (BTTS) market, we project a 58.3% chance of both Club Tijuana and Santos Laguna finding the net and a 41.7% chance that at least one doesn’t.

These predictions are based on each team's average score according to our machine learning model, which means the most likely correct score can differ from our predicted winner.

Game info & kickoff details

Sunday's Liga MX matchup between Club Tijuana and Santos Laguna at Estadio Caliente is scheduled to start at 11:10 PM ET.

• Who: Club Tijuana vs. Santos Laguna
• Date: Sunday, October 25, 2026
• Time: 11:10 PM ET/8:10 PM PT
• Venue: Estadio Caliente

Conclusion

According to our computer model, Club Tijuana has a 53.9% win probability on Sunday, Santos Laguna has a 23.5% win probability, and there is a 22.5% chance that the game will end in a draw.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary Liga MX prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.