NFL picks against the spread for Week 2, 2025

As part of our comprehensive NFL betting coverage, Dimers.com offers a weekly list of NFL picks against the spread, and for Week 2, we've harnessed our advanced predictive analytics model to deliver NFL spread picks for all 16 games.

With professional NFL picks against spread for every game on the Week 2 NFL slate, our expert predictive model is here to guide you through another huge week of football.

Below, you'll find a detailed list of each team's chances of covering the spread on , based on thousands of simulations of every game. These NFL predictions for Week 2 show the probability of each team covering the spread in their respective games.

While the picks in this article are based purely on probabilities, it's crucial for bettors to note that the best betting value may come from better odds available elsewhere.

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NFL spread picks: Week 2, 2025

Washington Commanders vs. Green Bay Packers (-3.5)

The opening game of Week 2 features the Packers hosting the Commanders, with the Packers listed as a 3.5-point favorite.

After 10,000 simulations of this matchup, our expertly tuned model projects the Commanders as having a 56% chance of covering the spread, while the Packers have a 44% chance.

• Pick ATS: Commanders +3.5

Los Angeles Rams vs. Tennessee Titans (+5.5)

Simulations show a 54% chance of the Titans (+5.5) covering the spread at Nissan Stadium, while the Rams have a 46% chance.

• Pick ATS: Titans +5.5

Seattle Seahawks vs. Pittsburgh Steelers (-3)

The Steelers are listed as -3 favorites against the Seahawks this week.

Our model projects the Seahawks as the more likely team to cover, with a probability of 56%, compared to 44% for the Steelers.

• Pick ATS: Seahawks +3

Buffalo Bills vs. New York Jets (+6.5)

Our simulations give the Bills a 43% chance of covering the +6.5 spread on the road against the Jets, who have a 57% chance.

• Pick ATS: Jets +6.5

For those interested in betting on the spread, the oddsmakers have listed the Jets at -110 to cover and the Bills at -115.

Chicago Bears vs. Detroit Lions (-6.5)

At home against the Bears, the Lions are 6.5-point favorites.

Our model projects that the sportsbooks have nailed this one, with a 50-50 chance of either team covering the spread.

However, when searching for a pick, the Lions get a slight lean.

• Pick ATS: Lions -6.5

New York Giants vs. Dallas Cowboys (-5.5)

Our model projects a 58% chance of the Giants covering the spread against the Cowboys, who have a 42% chance.

The line is set with the Cowboys as 5.5-point favorites at home.

• Pick ATS: Giants +5.5

Cleveland Browns vs. Baltimore Ravens (-11.5)

In this game at M&T Bank Stadium, the Ravens are 11.5-point favorites at home.

According to our model, both sides have an equal 50% chance of covering, with the slight lean going to the Ravens.

• Pick ATS: Ravens -11.5

San Francisco 49ers vs. New Orleans Saints (+3)

Our model predicts the Saints to cover the spread in this matchup, giving them a slight edge in what is essentially a 50-50 projection against the 49ers.

• Pick ATS: Saints +3

For those looking to place a bet, the line is set at 49ers -3, with the odds at -105 for the Saints to cover at home and -110 for the 49ers to cover on the road.

New England Patriots vs. Miami Dolphins (-1.5)

Our simulations suggest a 58% chance of the Dolphins covering the spread, while the Patriots have a 42% chance.

The hosting Dolphins are slight favorites with a 1.5-point spread in Week 2 against the Patriots.

• Pick ATS: Dolphins -1.5

Jacksonville Jaguars vs. Cincinnati Bengals (-3.5)

The Bengals enter this matchup as 3.5-point favorites at home against the Jaguars.

According to our simulations, both the Bengals and Jaguars have a 50% chance of covering, with the Bengals slightly favored for those in against the spread pick contests.

• Pick ATS: Bengals -3.5

For those interested in betting on this line, the Bengals are listed at -105 to cover, with the Jaguars at -110.

Carolina Panthers vs. Arizona Cardinals (-6.5)

Our model rates both the Cardinals and Panthers as having a 50-50 shot of covering. If you're looking to make a pick here, our slight lean goes to the Cardinals.

• Pick ATS: Cardinals -6.5

Denver Broncos vs. Indianapolis Colts (+2.5)

Both the Colts and Broncos have a 50% chance of covering the spread on Sunday afternoon.

However, our pick is the Colts, who covered the spread in slightly more of the 10,000 simulations we ran for the game at Lucas Oil Stadium.

• Pick ATS: Colts +2.5

Philadelphia Eagles vs. Kansas City Chiefs (+1.5)

We've run our powerful NFL model 10,000 times for this week’s Eagles-Chiefs clash, with our model unable to split the two teams at the line.

With the sportsbooks nailing the 1.5-point gap between the teams, our pick is the Colts to cover, who have a slightly higher probability.

• Pick ATS: Eagles -1.5

Atlanta Falcons vs. Minnesota Vikings (-3.5)

Our simulations indicate a 50-50 chance of both the Vikings and Falcons covering in this matchup.

However, the Vikings emerged as the pick in slightly more simulations, making the home team our pick against the spread for the Week 2 game at U.S. Bank Stadium.

• Pick ATS: Vikings -3.5

Tampa Bay Buccaneers vs. Houston Texans (-2.5)

We are picking the Buccaneers to cover the spread in their game against the Texans this week.

According to our trusted NFL model, there is a 58% chance that the road team will cover the +2.5 line, while the Texans have a 42% chance on Monday Night Football.

• Pick ATS: Buccaneers +2.5

Los Angeles Chargers vs. Las Vegas Raiders (+3.5)

The final game of Week 2 features the Raiders taking on the Chargers at Allegiant Stadium.

We are picking the Chargers to cover the spread, with a projected 58% chance of covering, while the Raiders have a 42% likelihood of covering the spread.

• Pick ATS: Chargers -3.5

Complete list of NFL Week 2 picks against the spread

• Commanders +3.5 (56%)
• Titans +5.5 (54%)
• Seahawks +3 (56%)
• Jets +6.5 (57%)
• Lions -6.5 (slight lean)
• Giants +5.5 (58%)
• Ravens -11.5 (slight lean)
• Saints +3 (slight lean)
• Dolphins -1.5 (58%)
• Bengals -3.5 (slight lean)
• Cardinals -6.5 (slight lean)
• Colts -2.5 (slight lean)
• Eagles -1.5 (53%)
• Vikings -3.5 (slight lean)
• Buccaneers +2.5 (58%)
• Chargers -3.5 (58%)

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Week 2 NFL picks against the spread

The NFL Week 2 picks against the spread in this article are accurate at the time of publication and may be subject to change.

Football fans across the country rely on our NFL expert picks against the spread because Dimers.com is the best website for NFL predictions.

If you choose to use our NFL spread picks for betting, it's important that you gamble responsibly and know when to stop. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Please note that all NFL odds and probabilities on this page are subject to change.

Conclusion

Our NFL Week 2 picks against the spread start with the Commanders +3.5 at a 56% probability on Thursday Night Football.

For more Week 2 betting tools, explore our NFL odds, NFL prop bets, NFL trends and NFL futures.