Saints vs. Giants prediction favors New Orleans to win in NFL Week 6 [2026]

Since our Saints-Giants predictions earlier in the week, we have re-simulated the outcome of Sunday's NFL game between the Saints and Giants, forming part of our NFL predictions coverage.

Our independent predictive model gives the Saints a 54.1% chance of beating the Giants in Week 6 of the NFL season. Our predicted final score has the Saints winning 23-22.

Key factors favoring the Saints:

• Saints QB situation
• Giants offense
• Giants defense

According to our model, the Saints (+1.5) have a 54.2% chance of covering the spread, while the over/under total of 46.5 points has a 51.3% chance of staying under.

Here's what's driving the under's higher probability::

• Saints recent performance
• Giants pace

To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.

Latest betting odds

We have researched the best NFL odds in America for this game, which are listed here:

• Spread: Saints +1.5 (-111) / Giants -1.5 (+108)
• Moneyline: Saints +100, Giants +100
• Total: Over/Under 46.5 (+106/-108)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Saints +1.5 @ 53¢ via Novig
• Moneyline: Saints @ 50¢ via Novig
• Total: Over 46.5 @ 49¢ via Novig

According to our NFL best bets, the top play to make on this game is Saints to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Saints vs. Giants TD scorers

Who will score a touchdown in Saints vs. Giants?

According to our list of touchdown scorer predictions for Week 6, Cam Skattebo is most likely to score an anytime TD in Saints vs. Giants.

Our projections give Skattebo a 41.8% chance of getting in for six at MetLife Stadium, while the running back is a 9.4% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

New Orleans Saints

• Chris Olave (WR): 35.8% probability
• Kendre Miller (RB): 35.0%
• Alvin Kamara (RB): 30.7%
• Juwan Johnson (TE): 26.5%
• Devaughn Vele (WR): 23.1%

New York Giants

• Cam Skattebo (RB): 41.8% prob.
• Isaiah Likely (TE): 38.0%
• Malik Nabers (WR): 33.6%
• Najee Harris (RB): 25.6%
• Malachi Fields (WR): 16.8%

First touchdown scorer predictions

New Orleans Saints

• Chris Olave (WR): 8.7% prob.
• Kendre Miller (RB): 8.5%
• Alvin Kamara (RB): 7.2%
• Juwan Johnson (TE): 6.0%
• Devaughn Vele (WR): 5.1%

New York Giants

• Cam Skattebo (RB): 9.4% prob.
• Isaiah Likely (TE): 8.3%
• Malik Nabers (WR): 7.1%
• Najee Harris (RB): 5.1%
• Malachi Fields (WR): 3.2%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Saints and Giants. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 6 games.

Quarterbacks

Of the starting quarterbacks, the Saints' Tyler Shough is projected for 245 passing yards, while the Giants' Jameis Winston is expected to throw for 225 yards.

Saints rushing

• Kendre Miller: 37 yds
• Alvin Kamara: 32 yds
• Tyler Shough: 16 yds

Giants rushing

• Cam Skattebo: 49 yds
• Najee Harris: 40 yds
• Jameis Winston: 11 yds

Saints receiving

• Chris Olave: 83 yds
• Devaughn Vele: 48 yds
• Juwan Johnson: 44 yds
• Bryce Lance: 19 yds
• Alvin Kamara: 16 yds

Giants receiving

• Malik Nabers: 76 yds
• Isaiah Likely: 55 yds
• Malachi Fields: 30 yds
• Darnell Mooney: 26 yds
• Cam Skattebo: 12 yds

Game info & kickoff details

The NFL Week 6 game between the Giants and Saints at MetLife Stadium is scheduled to commence at 1:00 PM ET.

• Who: New Orleans Saints vs. New York Giants
• Date: Sunday, October 18, 2026
• Time: 1:00 PM ET/10:00AM PT
• Venue: MetLife Stadium

NFL Week 6 promo

Make the most of Dimers' Saints vs. Giants predictions by exploring the below DraftKings Predicts offer:

Conclusion

We predict the Saints, with a 54.1% win probability, will likely beat the Giants in Week 6 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.