Cardinals vs. Rams prediction favors Rams to win in NFL Week 6 [2026]

Since our Cardinals-Rams predictions earlier in the week, we have re-simulated the outcome of Sunday's NFL matchup between the Cardinals and Rams, forming part of our NFL predictions coverage.

Our famous predictive model gives the Rams an 85.0% chance of defeating the Cardinals in Week 6 of the NFL season. Our predicted final score has the Rams winning 31-19.

Key factors favoring the Rams:

• Rams offense
• Rams team rating
• Cardinals defense

According to our model, the Cardinals (+13.5) have a 52.5% chance of covering the spread, while the over/under total of 51.5 points has a 55.0% chance of staying under.

Here's what's driving the under's higher probability::

• Cardinals recent performance
• QB ratings

To see win probabilities for every matchup this week, check out our expert NFL Week 6 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Cardinals +13.5 (-117) / Rams -13.5 (+113)
• Moneyline: Cardinals +669, Rams -733
• Total: Over/Under 51.5 (+100/-102)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Rams -13.5 @ 47¢ via Polymarket
• Moneyline: Cardinals @ 13¢ via Novig
• Total: Under 51.5 @ 50¢ via Novig

According to our best NFL bets, the top play to make on this game is Under 51.5 total points.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Cardinals vs. Rams TD scorers

Who will score a touchdown in Cardinals vs. Rams?

According to our list of touchdown scorer predictions for today, Kyren Williams is most likely to score an anytime TD in Cardinals vs. Rams.

Our projections give Williams a 61.1% chance of scoring a TD at SoFi Stadium, while the running back is a 14.7% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Arizona Cardinals

• Trey McBride (TE): 38.9% probability
• Tyler Allgeier (RB): 37.5%
• Michael Wilson (WR): 33.5%
• Bam Knight (RB): 15.9%
• Kendrick Bourne (WR): 15.2%

Los Angeles Rams

• Kyren Williams (RB): 61.1% prob.
• Puka Nacua (WR): 55.0%
• Davante Adams (WR): 49.0%
• Blake Corum (RB): 31.5%
• Tyler Higbee (TE): 28.8%

First touchdown scorer predictions

Arizona Cardinals

• Trey McBride (TE): 8.6% prob.
• Tyler Allgeier (RB): 8.2%
• Michael Wilson (WR): 7.1%
• Bam Knight (RB): 3.0%
• Kendrick Bourne (WR): 2.9%

Los Angeles Rams

• Kyren Williams (RB): 14.7% prob.
• Puka Nacua (WR): 12.5%
• Davante Adams (WR): 10.5%
• Blake Corum (RB): 5.9%
• Tyler Higbee (TE): 5.3%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Rams. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 6 games.

Quarterbacks

Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected for 245 passing yards, while the Rams' Matthew Stafford is expected to throw for a whopping 289 yards.

Cardinals rushing

• Tyler Allgeier: 49 yds
• Bam Knight: 20 yds
• Jacoby Brissett: 12 yds

Rams rushing

• Kyren Williams: 77 yds
• Blake Corum: 49 yds
• Puka Nacua: 4 yds

Cardinals receiving

• Trey McBride: 66 yds
• Michael Wilson: 65 yds
• Kendrick Bourne: 37 yds
• Jalen Brooks: 26 yds
• Tyler Allgeier: 17 yds

Rams receiving

• Puka Nacua: 99 yds
• Davante Adams: 64 yds
• Tyler Higbee: 37 yds
• Kyren Williams: 26 yds
• Colby Parkinson: 18 yds

Game info & kickoff details

The NFL Week 6 matchup between the Rams and Cardinals at SoFi Stadium is scheduled to start at 4:05 PM ET.

• Who: Arizona Cardinals vs. Los Angeles Rams
• Date: Sunday, October 18, 2026
• Time: 4:05 PM ET/1:05PM PT
• Venue: SoFi Stadium

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Conclusion

We predict the Rams, with an 85.0% win probability, will likely beat the Cardinals in Week 6 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.