Panthers vs. Saints prediction favors New Orleans to win in NFL Week 10 [2026]

Since our Panthers-Saints predictions earlier in the week, we have re-simulated the result of Sunday's NFL game between the Panthers and Saints, forming part of our NFL predictions coverage.

Our famous predictive model currently gives the Saints a 57.2% chance of beating the Panthers in Week 10 of the NFL season. Our predicted final score has the Saints winning 25-23.

Key factors favoring the Saints:

• Saints QB situation
• Panthers offense
• Saints team rating

According to our model, the Saints (-1.5) have a 51.5% chance of covering the spread, while the 48.5-point over/under has a 51.9% chance of going over.

The key factors that make the over more likely are:

• Playing conditions
• QB ratings

To see win probabilities for every matchup this week, check out our expert NFL Week 10 straight up picks.

Latest betting odds

We have sourced the best NFL odds in America for this game, which are listed here:

• Spread: Panthers +1.5 (+102) / Saints -1.5 (-104)
• Moneyline: Panthers +117, Saints -117
• Total: Over/Under 48.5 (-104/+102)

All odds are correct at the time of publication and are subject to change.

Model picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:

• Spread: Saints -1.5 @ 51¢ via Novig
• Moneyline: Saints @ 54¢ via Novig
• Total: Over 48.5 @ 51¢ via Novig

According to our NFL best bets, the top play to make on this game is Saints to win.

These picks are based on our probabilities matched against the implied probabilities from the current available odds.

Panthers vs. Saints TD scorers

Who will score a touchdown in Panthers vs. Saints?

According to our model, Chuba Hubbard is most likely to score an anytime touchdown in Panthers vs. Saints.

Our projections give Hubbard a 56.0% chance of scoring a TD at Caesars Superdome, while the running back is a 14.0% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Carolina Panthers

• Chuba Hubbard (RB): 56.0% probability
• Tetairoa McMillan (WR): 33.0%
• Jalen Coker (WR): 30.6%
• Darren Waller (TE): 23.6%
• Tommy Tremble (TE): 15.9%

New Orleans Saints

• Chris Olave (WR): 34.3% prob.
• Travis Etienne (RB): 34.0%
• Audric Estime (RB): 28.2%
• Juwan Johnson (TE): 25.7%
• Jordyn Tyson (WR): 24.3%

First touchdown scorer predictions

Carolina Panthers

• Chuba Hubbard (RB): 14.0% prob.
• Tetairoa McMillan (WR): 6.8%
• Jalen Coker (WR): 6.2%
• Darren Waller (TE): 4.6%
• Tommy Tremble (TE): 2.9%

New Orleans Saints

• Chris Olave (WR): 7.5% prob.
• Travis Etienne (RB): 7.4%
• Audric Estime (RB): 5.9%
• Juwan Johnson (TE): 5.3%
• Jordyn Tyson (WR): 5.0%

Top player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Panthers and Saints. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 10 games.

Quarterbacks

Of the starting quarterbacks, the Panthers' Bryce Young is projected for 255 passing yards, while the Saints' Tyler Shough is expected to throw for a whopping 261 yards.

Panthers rushing

• Chuba Hubbard: 81 yds
• Trevor Etienne: 13 yds
• Bryce Young: 12 yds

Saints rushing

• Travis Etienne: 34 yds
• Audric Estime: 28 yds
• Tyler Shough: 19 yds

Panthers receiving

• Tetairoa McMillan: 69 yds
• Jalen Coker: 57 yds
• Darren Waller: 33 yds
• Chuba Hubbard: 22 yds
• Tommy Tremble: 21 yds

Saints receiving

• Chris Olave: 79 yds
• Jordyn Tyson: 46 yds
• Devaughn Vele: 37 yds
• Juwan Johnson: 31 yds
• Alvin Kamara: 19 yds

Game info & kickoff details

The NFL Week 10 game between the Saints and Panthers at Caesars Superdome is scheduled to begin at 1:00 PM ET.

• Who: Carolina Panthers vs. New Orleans Saints
• Date: Sunday, November 15, 2026
• Time: 1:00 PM ET/10:00 AM PT
• Venue: Caesars Superdome

NFL Week 10 promo

Make the most of Dimers' Panthers vs. Saints predictions by exploring the below DraftKings Predicts offer:

Conclusion

We predict the Saints, with a 57.2% win probability, will likely beat the Panthers in Week 10 of the NFL season.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

This article's predictions and probabilities are generated by Dimers' proprietary NFL prediction model. Our editorial team reviews the resulting content for accuracy and presentation before publication.