NFL picks straight up: Week 10, 2026

At Dimers, our Week 10 NFL picks are grounded in data-driven insight, with straight-up picks for all 14 games informed by our latest NFL predictions.

Secure an advantage in your NFL pick 'em competitions by following our data-driven NFL Week 10 picks straight up, powered by thousands of game simulations.

Week 10 of the NFL season begins with the Washington Commanders facing the New York Giants on Thursday night and ends with the Los Angeles Chargers taking on the Baltimore Ravens on Monday.

NFL picks this week straight up: Week 10, 2026

Here are our Week 10 NFL picks highlighting each team's chances of winning their game this week.

Washington Commanders vs. New York Giants

The Commanders kick off Week 10 against the Giants at MetLife Stadium on Thursday night. According to our NFL model, the Giants have a 58% chance of winning, while the Commanders have a 42% chance.

For Week 10's opening game, our model highlights NFL player projections, with Rachaad White (RB) the most likely player from the Commanders to score the first TD at 7.6%, while Cam Skattebo (RB) is the top candidate from the Giants at 9.6%.

Check out our full Washington Commanders vs. New York Giants prediction ahead of this week's matchup at MetLife Stadium, set for Thursday, November 12 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

New England Patriots vs. Detroit Lions

For this week's game between the Patriots and the Lions, Detroit is more likely to win. Our prediction model gives the Lions a 59% chance of winning. On the other hand, there is a 41% chance that the Patriots will win.

Explore the latest data in this week's New England Patriots vs. Detroit Lions prediction before kickoff in Detroiton Sunday at 9:30am.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Kansas City Chiefs vs. Atlanta Falcons

We are picking the Chiefs to win their game against the Falcons this week, with our famous NFL model projecting a 63% win probability for the road team. The Falcons have a 37% chance of winning at Mercedes-Benz Stadium.

For betting purposes, the Falcons are listed as +3 underdogs, with the Chiefs' moneyline at -172.

Find the complete Kansas City Chiefs vs. Atlanta Falcons prediction for a closer look at Sunday's 1:00pm game.

Buffalo Bills vs. New York Jets

According to our predictive analytics model, the Bills are the team to beat in this game, with their win probability at 75%. The Jets, on the other hand, have a 25% chance of winning.

Review the edges and numbers in our Buffalo Bills vs. New York Jets prediction for this Sunday 1:00pm clash at MetLife Stadium.

Miami Dolphins vs. Indianapolis Colts

The Colts have a 61% chance of winning on Sunday afternoon, compared to the Dolphins' 39% chance of victory. This makes the Indianapolis Colts our pick to win at Lucas Oil Stadium.

See the numbers behind this matchup in the full Miami Dolphins vs. Indianapolis Colts prediction scheduled for Sunday at 1:00pm at Lucas Oil Stadium.

Minnesota Vikings vs. Green Bay Packers

The Packers are favorites to win here, with our model giving them a 61% chance, while the Vikings enter the weekend with a 39% chance of causing an upset at Lambeau Field.

When it comes to betting on this game, the Vikings' moneyline odds are set at +140, with the home team Packers listed as -3 favorites.

This week's Minnesota Vikings vs. Green Bay Packers prediction highlights the top values for the game at Lambeau Field on Sunday, November 15 at 1:00pm.

Carolina Panthers vs. New Orleans Saints

After 10,000 simulations of Panthers vs. Saints this Sunday, our model projects the Saints as the more likely winners with a probability of 59%. Their opponents, the Panthers, have a 41% chance of getting the win on the road.

Compare projections and odds for this matchup in our Carolina Panthers vs. New Orleans Saints prediction, set for Sunday at 1:00pm.

Jacksonville Jaguars vs. Tennessee Titans

Our model is picking the Jaguars, who have an 82% chance of winning the game, while the Titans have an 18% chance of an upset win.

Access the full data breakdown in our Jacksonville Jaguars vs. Tennessee Titans prediction ahead of kickoff at Nissan Stadium.

Houston Texans vs. Cleveland Browns

The next game of Week 10 sees the Texans take on the Browns at Huntington Bank Field.

We predict the Texans to win with a probability of 67%, while the Browns are projected to have a win chance of 33%.

As for the Vegas betting odds here, the Browns are listed as +5 underdogs, with the Texans' moneyline odds posted at -225.

Breakdown further probabilities and player projections in the Houston Texans vs. Cleveland Browns prediction for Sunday, November 15 at 1:00pm.

Seattle Seahawks vs. Las Vegas Raiders

The likely winner of this matchup is the Seahawks, who have a projected win chance of 72%, according to DimersBOT. On the other side of this matchup, the Raiders have a projected win probability of 28%.

Check out our Seattle Seahawks vs. Las Vegas Raiders prediction to see where the rest of the numbers lean ahead of Sunday's game in Las Vegas.

Los Angeles Rams vs. Arizona Cardinals

We have run our powerful NFL model over this week’s Rams-Cardinals clash 10,000 times, with the Rams coming out as the team to pick. Of those 10,000 simulations, the Rams won 7,834 times, with the Cardinals winning on 2,166 occasions.

Get direct access to more game projections with our Los Angeles Rams vs. Arizona Cardinals prediction before Sunday's clash at State Farm Stadium

San Francisco 49ers vs. Dallas Cowboys

Next up is the game between the 49ers and Cowboys, with our model projecting the road team as the more likely victor, with the 49ers rated as having a 65% chance of getting the W. The Cowboys, on the other hand, are projected to have a 35% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the 49ers' moneyline odds set at -205 for this road game, while the hosting Cowboys are listed as +4 underdogs.

Examine further probabilities in the full San Francisco 49ers vs. Dallas Cowboys prediction, scheduled for Sunday at 4:25pm.

Pittsburgh Steelers vs. Cincinnati Bengals

Our next straight up pick this week is for the Bengals to get the win against the Steelers. After running 10,000 simulations of this matchup, the Cincinnati have a win probability of 66%, with the Steelers at 34%.

View the complete Pittsburgh Steelers vs. Cincinnati Bengals prediction for a deeper look at this Sunday's game in Cincinnati.

Los Angeles Chargers vs. Baltimore Ravens

With a win probability of 67% on Monday night, our straight up pick for this matchup is the Ravens, while their opponent, the Chargers, have a projected win chance of 33%.

Check out the latest projections in this week's Los Angeles Chargers vs. Baltimore Ravens prediction before kickoff on Monday, November 16 at 8:15pm.

Full list of NFL Week 10 picks straight up

This week's most likely NFL winners, ordered by probability:

• Jaguars 82.4% @ Titans
• Rams 78.3% @ Cardinals
• Bills 75.1% @ Jets
• Seahawks 71.9% @ Raiders
• Ravens 67.5% vs. Chargers
• Texans 66.5% @ Browns
• Bengals 65.6% vs. Steelers
• 49ers 64.8% @ Cowboys
• Chiefs 62.8% @ Falcons
• Packers 60.8% vs. Vikings
• Colts 60.5% vs. Dolphins
• Lions 59.5% vs. Patriots
• Saints 59.2% vs. Panthers
• Giants 57.8% vs. Commanders

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NFL straight up picks and predictions for Week 10

The NFL Week 10 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.