MLB picks today: Wednesday's MLB best bets include Padres vs. Diamondbacks play [8/5/2026]

Today’s MLB picks for August 5, 2026 are here, with Padres vs. Diamondbacks and Tigers vs. Mariners among the top plays identified by our model across Wednesday’s MLB slate.

Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to uncover real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLB best bets tonight [8/5, updated 9:16PM ET]

Below, you’ll find today’s MLB best bets, ranked by edge for Wednesday, August 5, 2026.

Padres vs. Diamondbacks Over 8.5 runs (-105)

• Edge: 8.9%
• Probability: 60.1%
• Matchup: Padres vs. Diamondbacks (9:40PM ET)

Our model has identified value on Over 8.5 runs in Padres vs. Diamondbacks at -105 odds. A 60.1% probability produces an edge of 8.9%, making this the strongest play for today's MLB slate.

Tigers vs. Mariners Over 7.5 runs (-106)

• Edge: 3.9%
• Probability: 55.3%
• Matchup: Tigers vs. Mariners (9:40PM ET)

Tigers vs. Mariners over 7.5 runs carries a 3.9% edge and a probability of 55.3% at -106 odds, according to our model.

Diamondbacks ML (+127)

• Edge: 3.1%
• Probability: 47.1%
• Matchup: Padres vs. Diamondbacks (9:40PM ET)

Diamondbacks ML at +127 odds shows a 3.1% edge, supported by a 47.1% probability in simulations.

MLB best bets summary: Wednesday, 8/5/2026

As of 9:16PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [8/5/2026]

• Tigers vs. Mariners (9:40PM ET, Wednesday)
• Padres vs. D-Backs (9:40PM ET, Wednesday)
• Angels vs. Orioles (12:35PM ET, Thursday)
• Athletics vs. Reds (12:40PM ET, Thursday)
• Mets vs. Guardians (1:10PM ET, Thursday)
• Pirates vs. Brewers (2:10PM ET, Thursday)
• Blue Jays vs. Cubs (2:20PM ET, Thursday)
• Tigers vs. Mariners (4:10PM ET, Thursday)
• Nationals vs. Phillies (6:05PM ET, Thursday)
• White Sox vs. Red Sox (7:10PM ET, Thursday)
• Marlins vs. Braves (7:15PM ET, Thursday)
• Twins vs. Royals (7:40PM ET, Thursday)

Conclusion

Our MLB best bets are locked and loaded for August 5, 2026, featuring plays such as over 8.5 runs in the Padres vs. Diamondbacks matchup and over 7.5 runs in the Tigers vs. Mariners matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.