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Eagles vs. Commanders prediction: Why Philadelphia is favored to win in NFL Week 16 [2025]

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Written by Mac Douglass

Get Philadelphia Eagles vs Washington Commanders predictions for NFL Saturday.

Philadelphia Eagles-Washington Commanders Predictions and Game Preview.
Philadelphia Eagles vs. Washington Commanders NFL prediction for Saturday, December 20, 2025.

The Washington Commanders will square off with the favored Philadelphia Eagles in NFL Week 16 action at Northwest Stadium on Saturday, commencing at 5:00 PM ET.

Based on updated simulation results, Dimers' advanced NFL model predicts the Eagles as the most likely winner of the Eagles vs. Commanders game.

This article offers further insights into this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Eagles vs. Commanders prediction: Who will win and cover?

Since our Eagles-Commanders predictions earlier in the week, we have simulated the outcome of Saturday's NFL game between the Eagles and Commanders 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Eagles a 70% chance of beating the Commanders in Week 16 of the NFL season. Our predicted final score has the Eagles winning 25-19.

According to our model, the Commanders (+7) have a 57% chance of covering the spread, while the over/under total of 44.5 points has a 55% chance of going over.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 16 straight up picks.

Eagles vs. Commanders odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type Eagles Commanders
Spread -7 (-106) +7 (-108)
Moneyline -345 +275
Total o44.5 (-105) u44.5 (-110)

All odds are correct at the time of publication and are subject to change.

Eagles vs. Commanders picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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