NFL picks straight up: Week 8, 2025

At Dimers.com, we provide NFL picks straight up for Week 8 and every week, as part of our comprehensive NFL picks and NFL predictions coverage.

With Week 8 of the NFL season here, we've used our cutting-edge predictive analytics model to deliver a list of NFL straight up picks for all 13 games this week.

Gain the edge in your NFL pick 'em contests by following our data-driven NFL Week 8 picks straight up, powered by thousands of game simulations.

Week 8 of the NFL season features 13 games, beginning with the Minnesota Vikings facing the Los Angeles Chargers on Thursday night and wrapping up with the Washington Commanders taking on the Kansas City Chiefs on Sunday.

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Full list of NFL Week 8 picks straight up

• Chargers (59% win probability)
• Bengals (72%)
• Bills (74%)
• Texans (56%)
• Eagles (74%)
• Patriots (76%)
• Ravens (70%)
• Falcons (75%)
• Buccaneers (63%)
• Broncos (60%)
• Colts (90%)
• Packers (62%)
• Chiefs (81%)

NFL picks this week straight up: Week 8, 2025

Listed below are our Week 8 NFL picks, highlighting how likely each team is to win their game this week.

Minnesota Vikings vs. Los Angeles Chargers

The Vikings kick off Week 8 against the Chargers at SoFi Stadium on Thursday night. According to our model, the Chargers have a 59% chance of winning, while the Vikings have a 41% chance.

For Week 8's opening game, our model highlights NFL player props with Jordan Mason (RB) as the most likely player from the Vikings to score the first TD at 12.2%, while Hassan Haskins (RB) is the top candidate from the Chargers at 11.2%.

The Minnesota Vikings vs. Los Angeles Chargers game at SoFi Stadium is scheduled for Thursday, October 23 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

New York Jets vs. Cincinnati Bengals

For this week's game between the Jets and the Bengals, Cincinnati is more likely to win. Our prediction model gives the Bengals a 72% chance of winning. On the other hand, there is a 28% chance that the Jets will pull off an upset win.

The New York Jets vs. Cincinnati Bengals matchup at Paycor Stadium will take place on Sunday, October 26 at 1:00pm.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Buffalo Bills vs. Carolina Panthers

We are picking the Bills to win their game against the Panthers this week, with our trusted NFL model projecting a 74% win probability for the road team. The Panthers have a 26% chance of winning.

For betting purposes, the Panthers are listed as +7.5 underdogs, with the Bills' moneyline at -360.

The Buffalo Bills vs. Carolina Panthers game at Bank of America Stadium is slated for Sunday, October 26 at 1:00pm.

San Francisco 49ers vs. Houston Texans

According to our predictive analytics model, the Texans are the team to beat in this game, with their win probability at 56%. The 49ers, on the other hand, have a 44% chance of winning.

The San Francisco 49ers vs. Houston Texans game at NRG Stadium is set for Sunday, October 26 at 1:00pm.

New York Giants vs. Philadelphia Eagles

The Eagles have a 74% chance of winning on Sunday afternoon, compared to the Giants' 26% chance of victory. This makes the Philadelphia Eagles our pick to win at Lincoln Financial Field.

The New York Giants vs. Philadelphia Eagles matchup at Lincoln Financial Field is scheduled for Sunday, October 26 at 1:00pm.

Cleveland Browns vs. New England Patriots

The Patriots are favorites to win this one, with our predictive analytics model giving them a 76% chance, while the Browns enter the weekend with a 24% chance of causing an upset at Gillette Stadium.

When it comes to betting on this game, the Browns' moneyline odds are set at +290, with the home team Patriots listed as -7 favorites.

The Cleveland Browns vs. New England Patriots game at Gillette Stadium will take place on Sunday, October 26 at 1:00pm.

Chicago Bears vs. Baltimore Ravens

After 10,000 simulations of Bears vs. Ravens this Sunday, our model projects the Ravens as the more likely winners with a probability of 70%. Their opponents, the Bears, have a 30% chance of getting the win on the road.

The Chicago Bears vs. Baltimore Ravens matchup at M&T Bank Stadium is slated for Sunday, October 26 at 1:00pm.

Miami Dolphins vs. Atlanta Falcons

Our model is picking the Falcons, who have a 75% chance of winning the game, while the Dolphins have a 25% win probability.

The Miami Dolphins vs. Atlanta Falcons game at Mercedes-Benz Stadium will take place on Sunday, October 26 at 1:00pm.

Tampa Bay Buccaneers vs. New Orleans Saints

The next game of Week 8 sees the Buccaneers take on the Saints at Caesars Superdome.

We predict the Buccaneers to win with a probability of 63%, while the Saints are projected to have a win chance of 37%.

As for the Vegas betting odds here, the Saints are listed as +4.5 underdogs, with the Buccaneers' moneyline odds posted at -220.

The Tampa Bay Buccaneers vs. New Orleans Saints game at Caesars Superdome is scheduled for Sunday, October 26 at 4:05pm.

Dallas Cowboys vs. Denver Broncos

The likely winner of this matchup is the Broncos, who have a projected win chance of 60%, according to DimersBOT. On the other side of this matchup, the Cowboys have a projected win probability of 40%.

The Dallas Cowboys vs. Denver Broncos matchup at Empower Field at Mile High is set for Sunday, October 26 at 4:25pm.

Tennessee Titans vs. Indianapolis Colts

We have run our powerful NFL model over this week’s Titans-Colts clash 10,000 times, with the Colts coming out as the team to pick. Of those 10,000 simulations, the Colts won 8,958 times, with the Titans winning on 1,042 occasions.

The Tennessee Titans vs. Indianapolis Colts game at Lucas Oil Stadium is scheduled for Sunday, October 26 at 4:25pm.

Green Bay Packers vs. Pittsburgh Steelers

Next up is the game between the Packers and Steelers, with our model projecting the road team as the more likely victor, with the Packers rated as having a 62% chance of getting the W. The Steelers, on the other hand, are projected to have a 38% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Packers' moneyline odds set at -170 for this road game, while the hosting Steelers are listed as +3.5 underdogs.

The Green Bay Packers vs. Pittsburgh Steelers game at Acrisure Stadium will take place on Sunday, October 26 at 8:20pm.

Washington Commanders vs. Kansas City Chiefs

Our next straight up pick this week is for the Chiefs to get the win against the Commanders. After running 10,000 simulations of this matchup, the Kansas City have a win probability of 81%, with the Commanders at 19%.

The Washington Commanders vs. Kansas City Chiefs game at GEHA Field at Arrowhead Stadium is slated for Monday, October 27 at 8:15pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 8

The NFL Week 8 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.