Saints vs. Panthers prediction: Why Carolina is favored to win in NFL Week 10, 2025

The Carolina Panthers will square off with the New Orleans Saints in NFL Week 10 action at Bank of America Stadium on Sunday, commencing at 1:00PM ET.

Based on updated simulations, Dimers' proven NFL model predicts the Panthers as the most likely winner of the Saints vs. Panthers game.

This article offers further insights into Sunday's matchup, including touchdown scorer projections, best bets and player prop picks.

Saints vs. Panthers prediction: Who will win, cover the spread?

Since our Saints-Panthers predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Saints and Panthers 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Panthers a 72% chance of beating the Saints in Week 10 of the NFL season. Our predicted final score has the Panthers winning 22-16.

According to our model, the bookmakers have got it right, and the Saints and Panthers each have a 50% chance of covering the spread, while the 38.5-point over/under has a 53% chance of going over.

To see win probabilities for every matchup this week, check out our expert NFL Week 10 straight up picks.

Saints vs. Panthers odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Saints	Panthers
Spread	+5.5 (-112)	-5.5 (-105)
Moneyline	+205	-245
Total	o38.5 (-108)	u38.5 (-110)

All odds are correct at the time of publication and are subject to change.

Saints vs. Panthers picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Panthers -5.5	-105
Moneyline	Panthers	-245
Total	Over 38.5	-108

According to our NFL best bets, the top play to make on this game is Panthers to win.

Saints vs. Panthers TD scorers

Who will score a touchdown in Saints vs. Panthers?

According to our model, Rico Dowdle is most likely to score an anytime touchdown in Saints vs. Panthers.

Our projections give Dowdle a 52.5% chance of scoring a TD at Bank of America Stadium, while the running back is a 16.1% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

New Orleans Saints

Player	Anytime TD Probability
Alvin Kamara (RB)	29.6%
Chris Olave (WR)	27.5%
Juwan Johnson (TE)	24.2%
Taysom Hill (TE)	21.3%
Devin Neal (RB)	16.1%

Carolina Panthers

Player	Anytime TD Probability
Rico Dowdle (RB)	52.5%
Tetairoa McMillan (WR)	30.3%
Xavier Legette (WR)	20.2%
Chuba Hubbard (RB)	19.8%
Jalen Coker (WR)	18.1%

First touchdown scorer predictions

New Orleans Saints

Player	First TD Probability
Alvin Kamara (RB)	7.4%
Chris Olave (WR)	6.8%
Juwan Johnson (TE)	5.8%
Taysom Hill (TE)	5.1%
Devin Neal (RB)	3.7%

Carolina Panthers

Player	First TD Probability
Rico Dowdle (RB)	16.1%
Tetairoa McMillan (WR)	7.8%
Xavier Legette (WR)	4.9%
Chuba Hubbard (RB)	4.8%
Jalen Coker (WR)	4.3%

Saints vs Panthers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Saints and Panthers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 10 games.

Quarterbacks

Of the starting quarterbacks, the Saints' Tyler Shough is projected for 194 passing yards, while the Panthers' Bryce Young is expected to throw for just 189 yards.

Player	Proj. Pass Yards
Tyler Shough (NO)	194
Bryce Young (CAR)	189

Saints rushing

Player	Proj. Rush Yards
Alvin Kamara	40
Devin Neal	21
Taysom Hill	17

Panthers rushing

Player	Proj. Rush Yards
Rico Dowdle	93
Chuba Hubbard	26
Bryce Young	13

Saints receiving

Player	Proj. Rec. Yards
Chris Olave	61
Juwan Johnson	39
Devaughn Vele	27
Brandin Cooks	25
Alvin Kamara	18

Panthers receiving

Player	Proj. Rec. Yards
Tetairoa McMillan	54
Jalen Coker	34
Xavier Legette	32
Ja'Tavion Sanders	22
Rico Dowdle	17

Saints vs. Panthers game-day updates and essential details

The NFL Week 10 action between the Panthers and Saints at Bank of America Stadium is scheduled to start at 1:00PM ET.

• Who: New Orleans Saints vs. Carolina Panthers
• Date: Sunday, November 9, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium

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Conclusion

We predict the Panthers, with a 72% win probability, will likely beat the Saints in Week 10 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Saints vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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