NFL picks straight up: Week 10, 2025

At Dimers.com, we offer NFL picks straight up for Week 10 and beyond, as part of our extensive NFL picks and NFL predictions coverage.

With Week 10 of the NFL season here, we've harnessed our sophisticated predictive analytics model to deliver a list of NFL straight up picks for all 14 games this week.

Gain the edge in your NFL pick 'em contests via our data-driven NFL Week 10 picks straight up, powered by thousands of game simulations.

Week 10 of the NFL season features 14 games, beginning with the Las Vegas Raiders facing the Denver Broncos on Thursday night and concluding with the Philadelphia Eagles taking on the Green Bay Packers on Monday.

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Full list of NFL Week 10 picks straight up

• Broncos (81% win probability)
• Colts (70%)
• Ravens (63%)
• Buccaneers (58%)
• Texans (57%)
• Jets (56%)
• Panthers (71%)
• Bears (59%)
• Bills (78%)
• Seahawks (74%)
• Rams (60%)
• Lions (73%)
• Chargers (59%)
• Packers (62%)

NFL picks this week straight up: Week 10, 2025

Here are our Week 10 NFL picks, highlighting how likely each team is to win their game this week.

Las Vegas Raiders vs. Denver Broncos

The Raiders kick off Week 10 against the Broncos at Empower Field at Mile High on Thursday night. According to our model, the Broncos have an 81% chance of winning, while the Raiders have a 19% chance.

For Week 10's opening game, our model highlights NFL player props with Ashton Jeanty (RB) as the most likely player from the Raiders to score the first TD at 11.4%, while J.K. Dobbins (RB) is the top candidate from the Broncos at 10.6%.

The Las Vegas Raiders vs. Denver Broncos game at Empower Field at Mile High is scheduled for Thursday, November 6 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Atlanta Falcons vs. Indianapolis Colts

For this week's game between the Falcons and the Colts, Indianapolis is more likely to win. Our prediction model gives the Colts a 70% chance of winning. On the other hand, there is a 30% chance that the Falcons will win.

The Atlanta Falcons vs. Indianapolis Colts matchup at Olympic Stadium Berlin will take place on Sunday, November 9 at 9:30am.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Baltimore Ravens vs. Minnesota Vikings

We are picking the Ravens to win their game against the Vikings this week, with our powerful NFL model projecting a 63% win probability for the road team. The Vikings have a 37% chance of winning at U.S. Bank Stadium.

For betting purposes, the Vikings are listed as +4.5 underdogs, with the Ravens' moneyline at -210.

The Baltimore Ravens vs. Minnesota Vikings game at U.S. Bank Stadium is slated for Sunday, November 9 at 1:00pm.

New England Patriots vs. Tampa Bay Buccaneers

According to our predictive analytics model, the Buccaneers are the team to beat in this game, with their win probability at 58%. The Patriots, on the other hand, have a 42% chance of winning.

The New England Patriots vs. Tampa Bay Buccaneers game at Raymond James Stadium is set for Sunday, November 9 at 1:00pm.

Jacksonville Jaguars vs. Houston Texans

The Texans have a 57% chance of winning on Sunday afternoon, compared to the Jaguars' 43% chance of victory. This makes the Houston Texans our pick to win at NRG Stadium.

The Jacksonville Jaguars vs. Houston Texans matchup at NRG Stadium is scheduled for Sunday, November 9 at 1:00pm.

Cleveland Browns vs. New York Jets

The Jets are favorites to win their game this week, with our predictive analytics model giving them a 56% chance, while the Browns enter the weekend with a 44% chance of securing a win at MetLife Stadium.

When it comes to betting on this game, the Browns' moneyline odds are set at -100, with the home team Jets listed as -1.5 favorites.

The Cleveland Browns vs. New York Jets game at MetLife Stadium will take place on Sunday, November 9 at 1:00pm.

New Orleans Saints vs. Carolina Panthers

After 10,000 simulations of Saints vs. Panthers this Sunday, our model projects the Panthers as the more likely winners with a probability of 71%. Their opponents, the Saints, have a 29% chance of getting the win on the road.

The New Orleans Saints vs. Carolina Panthers matchup at Bank of America Stadium is slated for Sunday, November 9 at 1:00pm.

New York Giants vs. Chicago Bears

We are picking the Bears, who have a 59% chance of winning the matchup, while the Giants have a 41% win probability.

The New York Giants vs. Chicago Bears game at Soldier Field will take place on Sunday, November 9 at 1:00pm.

Buffalo Bills vs. Miami Dolphins

The next game of Week 10 sees the Bills take on the Dolphins at Hard Rock Stadium.

We predict the Bills to win with a probability of 78%, while the Dolphins are projected to have a win chance of 22%.

As for the Vegas betting odds here, the Dolphins are listed as +9.5 underdogs, with the Bills' moneyline odds posted at -470.

The Buffalo Bills vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Sunday, November 9 at 1:00pm.

Arizona Cardinals vs. Seattle Seahawks

The likely winner of this matchup is the Seahawks, who have a projected win chance of 74%, according to DimersBOT. On the other side of this matchup, the Cardinals have a projected win probability of 26%.

The Arizona Cardinals vs. Seattle Seahawks matchup at Lumen Field is set for Sunday, November 9 at 4:05pm.

Los Angeles Rams vs. San Francisco 49ers

We have run our powerful NFL model over this week’s Rams-49ers clash 10,000 times, with the Rams coming out as the team to pick. Of those 10,000 simulations, the Rams won 6,002 times, with the 49ers winning on 3,998 occasions.

The Los Angeles Rams vs. San Francisco 49ers game at Levi's Stadium is scheduled for Sunday, November 9 at 4:25pm.

Detroit Lions vs. Washington Commanders

Next up is the game between the Lions and Commanders, with our model projecting the road team as the more likely victor, with the Lions rated as having a 73% chance of getting the W. The Commanders, on the other hand, are projected to have a 27% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Lions' moneyline odds set at -480 for this road game, while the hosting Commanders are listed as +9 underdogs.

The Detroit Lions vs. Washington Commanders game at Northwest Stadium will take place on Sunday, November 9 at 4:25pm.

Pittsburgh Steelers vs. Los Angeles Chargers

Our next straight up pick this week is for the Chargers to get the win against the Steelers. After running 10,000 simulations of this matchup, the LA Chargers have a win probability of 59%, with the Steelers at 41%.

The Pittsburgh Steelers vs. Los Angeles Chargers game at SoFi Stadium is slated for Sunday, November 9 at 8:20pm.

Philadelphia Eagles vs. Green Bay Packers

With a win probability of 62% on Monday night, our straight up pick for this game is the Packers, while their opponent, the Eagles, have a projected win chance of 38%.

The Philadelphia Eagles vs. Green Bay Packers game at Lambeau Field will take place on Monday, November 10 at 8:15pm.

For a different angle on this week's NFL action, explore our NFL trends to spot the latest player prop trends.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 10

The NFL Week 10 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.