Rams vs. 49ers prediction: Rams favored to win in NFL Week 10, 2025

The San Francisco 49ers will square off with the favored Los Angeles Rams in NFL Week 10 action at Levi's Stadium on Sunday, beginning at 4:25PM ET.

Based on the latest simulation results, Dimers' advanced NFL model predicts the Rams as the most likely winner of the Rams vs. 49ers game.

This article offers further insights into this week's matchup, including touchdown scorer projections, best bets and player prop picks.

Rams vs. Niners prediction: Who will win, cover the spread?

Since our Rams-49ers predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Rams and 49ers 10,000 times as part of our NFL predictions coverage.

Our famous predictive model currently gives the Rams a 67% chance of defeating the 49ers in Week 10 of the NFL season. Our predicted final score has the Rams winning 27-22.

According to our model, the 49ers (+5.5) have a 54% chance of covering the spread, while the 49.5-point over/under has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 10 straight up picks.

Rams vs. 49ers odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Rams	49ers
Spread	-5.5 (-112)	+5.5 (-105)
Moneyline	-250	+210
Total	o49.5 (-110)	u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

Rams vs. 49ers picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	49ers +5.5	-105
Moneyline	49ers	+210
Total	Under 49.5	-110

According to our best NFL bets, the top play to make on this game is 49ers +5.5 at the spread.

Rams vs. 49ers TD scorers

Who will score a touchdown in Rams vs. 49ers?

According to our list of touchdown scorer predictions for today, Christian McCaffrey is most likely to score an anytime TD in Rams vs. 49ers.

Our projections give McCaffrey a 57.4% chance of scoring a TD at Levi's Stadium, while the running back is a 15.0% chance of registering the first touchdown the game.

Anytime touchdown scorer predictions

Los Angeles Rams

Player	Anytime TD Probability
Kyren Williams (RB)	51.4%
Davante Adams (WR)	50.5%
Puka Nacua (WR)	48.9%
Tyler Higbee (TE)	19.9%
Blake Corum (RB)	17.7%

San Francisco 49ers

Player	Anytime TD Probability
Christian McCaffrey (RB)	57.4%
George Kittle (TE)	34.6%
Jauan Jennings (WR)	26.4%
Kendrick Bourne (WR)	17.5%
Demarcus Robinson (WR)	11.2%

First touchdown scorer predictions

Los Angeles Rams

Player	First TD Probability
Kyren Williams (RB)	12.1%
Davante Adams (WR)	11.8%
Puka Nacua (WR)	11.2%
Tyler Higbee (TE)	3.7%
Blake Corum (RB)	3.2%

San Francisco 49ers

Player	First TD Probability
Christian McCaffrey (RB)	15.0%
George Kittle (TE)	7.5%
Jauan Jennings (WR)	5.4%
Kendrick Bourne (WR)	3.4%
Demarcus Robinson (WR)	2.1%

Rams vs 49ers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Rams and 49ers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 10 games.

Quarterbacks

Of the starting quarterbacks, the Rams' Matthew Stafford is projected to have a big game with 275 passing yards, while the 49ers' Mac Jones is expected to throw for 248 yards.

Player	Proj. Pass Yards
Matthew Stafford (LA)	275
Mac Jones (SF)	248

Rams rushing

Player	Proj. Rush Yards
Kyren Williams	71
Blake Corum	32
Matthew Stafford	3

49ers rushing

Player	Proj. Rush Yards
Christian McCaffrey	69
Brian Robinson	16
Mac Jones	10

Rams receiving

Player	Proj. Rec. Yards
Puka Nacua	97
Davante Adams	65
Tyler Higbee	25
Jordan Whittington	24
Kyren Williams	20

49ers receiving

Player	Proj. Rec. Yards
Jauan Jennings	54
George Kittle	52
Christian McCaffrey	49
Kendrick Bourne	38
Demarcus Robinson	21

Rams vs. Niners game-day updates and essential details

The NFL Week 10 game between the 49ers and Rams at Levi's Stadium is scheduled to commence at 4:25PM ET.

• Who: Los Angeles Rams vs. San Francisco 49ers
• Date: Sunday, November 9, 2025
• Time: 4:25PM ET/1:25PM PT
• Venue: Levi's Stadium

NFL Week 10 betting promos and codes

Make the most of Dimers' Rams vs. 49ers predictions by exploring the two exciting offers below.

DraftKings Sportsbook

Sign up for DraftKings Sportsbook! Bet $5, get $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

Bet365 Sportsbook

Join Bet365 Sportsbook! Bet $5, get $200 in bonus bets win or lose.

Sports betting deal available for Sunday

To make the most of Sunday's mammoth day of sports, headlined by NFL Sunday action, check out details on the latest Bet365 bonus code "DIMERS" that scores you $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict the Rams, with a 67% win probability, will likely beat the 49ers in Week 10 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Rams vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Stay up-to-date with the latest NFL news and NFL parlay picks throughout the season. Plus, our Super Bowl odds provide the latest probabilities for the Super Bowl, AFC, NFC and each division.

Boost your NFL betting by exploring the latest NFL betting promos, sourced from top sportsbooks and DFS operators.