Jacksonville Jaguars vs. Denver Broncos: Experts release early Week 16 projections [2025]

The Jacksonville Jaguars and Denver Broncos will meet in Week 16 of the NFL season at Empower Field at Mile High on Sunday, December 21, 2025, starting at 4:05PM ET.

Initial simulations from Dimers' trusted NFL model favor the Broncos as the most likely winner of this AFC showdown.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Jaguars vs. Broncos predictions page.

Jacksonville vs. Denver early predictions

Leveraging trusted machine learning and analysis, we have simulated the Jaguars vs. Broncos game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Jaguars 41%, Broncos 59%
• Predicted final score: Jaguars 20-22 Broncos
• Spread: Jaguars (+2.5) 50%, Broncos (-2.5) 50%
• Total points (43.5): Over 50%, Under 50%

As of December 15, 2025, these Jaguars-Broncos figures and predictions reflect the latest data and insights available.

Jaguars vs. Broncos Week 16 details

The NFL Week 16 matchup between the Broncos and Jaguars at Empower Field at Mile High is scheduled for December 21, 2025.

• Who: Jacksonville Jaguars vs. Denver Broncos
• Date: Sunday, December 21, 2025
• Time: 4:05PM ET/1:05PM PT
• Venue: Empower Field at Mile High

Jaguars vs. Broncos opening odds

We've researched the best betting odds across America for this Week 16 game, which are listed here:

• Spread: Jaguars +2.5 (+100), Broncos -2.5 (-110)
• Moneyline: Jaguars +124, Broncos -132
• Total: Over/Under 43.5 (-105/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Broncos, with a 59% win probability, will likely beat the Jaguars in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Jaguars vs. Broncos matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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