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Christian McCaffrey projections Week 16: Fantasy points, rushing yards vs. Colts [2025]
Get projected stats and fantasy points for Christian McCaffrey in Week 16, 2025.

Christian McCaffrey's projected stats suggest a strong fantasy score on Monday at 8:15 PM ET when his San Francisco 49ers face the Indianapolis Colts.
According to Dimers' NFL player projections, McCaffrey ranks as one of the top running back selections for Week 16.
Christian McCaffrey Week 16 fantasy football projection
With playoffs underway in most fantasy leagues, Dimers Pro members get full access to the latest data and analysis on McCaffrey in the 49ers vs. Colts matchup.
Based on advanced modeling, McCaffrey is projected for 22.0 fantasy points in PPR this week, and 19.9 in half-PPR, making him one of the premier running back selections.
Christian McCaffrey projected box score for Week 16
Here’s how our model breaks down McCaffrey's expected production against the Colts:
- Rushing yards: 69.2
- Receptions: 4.3
- Receiving yards: 38.0
- Anytime TD probability: 65.3%
- First TD probability: 18.8%
Conclusion
Christian McCaffrey's Week 16 fantasy football projections indicate a strong outlook, with the San Francisco 49ers RB's projected for 69 rushing yards against the Colts, giving him solid value for fantasy managers in both PPR and Half-PPR formats.
This article combines automation with human oversight to help you make informed decisions. If using our NFL props data or NFL predictions for betting, Dimers encourages responsible gambling.
