Christian McCaffrey projections Week 16: Fantasy points, rushing yards vs. Colts [2025]

Christian McCaffrey's projected stats suggest an impressive fantasy football performance on Monday at 8:15 PM ET when his San Francisco 49ers face the Indianapolis Colts.

According to Dimers' NFL player projections, McCaffrey ranks as one of the top running back prospects for Week 16.

Christian McCaffrey Week 16 fantasy football projection

With playoffs underway in most fantasy leagues, Dimers Pro members have full access to the latest insights and analysis on McCaffrey in the 49ers vs. Colts matchup.

Based on advanced data, McCaffrey is projected for 22.9 fantasy points in PPR this week, and 20.6 in half-PPR, making him one of the top running back plays.

Christian McCaffrey projected prop performance for Week 16

Here’s how our model breaks down McCaffrey's expected numbers against the Colts:

• Rushing yards: 65.7
• Receptions: 4.6
• Receiving yards: 41.7
• Anytime TD probability: 68.7%
• First TD probability: 19.3%

Conclusion

Christian McCaffrey's Week 16 fantasy football projections indicate a strong outlook, with the San Francisco 49ers RB's projected for 66 rushing yards against the Colts, giving him solid value for fantasy managers in both PPR and Half-PPR formats.

This article combines automation with human oversight to help you make informed decisions. If using our NFL props data or NFL predictions for betting, Dimers encourages responsible gambling.